Artículos de revistas
[study Of Patients With Cleft Lip And Palate With Consanguineous Parents].
Registro en:
Brazilian Journal Of Otorhinolaryngology. v. 77, n. 1, p. 19-23
1808-8686
21340184
Autor
Aquino, Sibele Nascimento de
Paranaíba, Lívia Máris Ribeiro
Martelli, Daniella Reis Barbosa
Swerts, Mário Sérgio Oliveira
Barros, Letízia Monteiro de
Bonan, Paulo Rogério Ferreti
Martelli Júnior, Hercílio
Institución
Resumen
Cleft lip and/or palate (CL/P) are the most common congenital anomalies of the face. CL/P are non-syndromic (CL/PNS) in about 70% of subjects. To describe clinical cases of non-syndromic CL/P (CL/PNS) associated with consanguinity, diagnosed at a reference hospital in Minas Gerais, Brazil, and to correlate these alterations with possible risk factors. SERIES AND METHODS: A retrospective study at a reference hospital for craniofacial deformities in Minas Gerais, Brazil from 2006 to 2009 based on data in medical records. Of 246 CL/PNS cases diagnosed and treated at the institution, 15 (6.1%) were CL/PNS with reported first-degree consanguinity; 73.3% occurred in males. Four of 15 patients had complete right cleft palate and lip (CLP), 4 presented complete cleft palate and lip (right and left), 3 had complete unilateral left CLP, 3 had isolated cleft palate, and 1 presented cleft lip only. Among the risk factors, only three mothers reported smoking during pregnancy. CLP (unilateral or bilateral) were more frequent in the group with a history of first-degree consanguinity; males predominated. Among the risk factors, only smoking was observed in three cases. 77 19-23