Artículos de revistas
Synthesis Of 4-aryl-2-pyrrolidones And Beta-aryl-gamma-amino-butyric Acid (gaba) Analogues By Heck Arylation Of 3-pyrrolines With Arenediazonium Tetrafluoroborates. Synthesis Of (+/-)-rolipram On A Multigram Scale And Chromatographic Resolution By Semipreparative Chiral Simulated Moving Bed Chromatography.
Registro en:
The Journal Of Organic Chemistry. v. 70, n. 3, p. 1050-3, 2005-Feb.
0022-3263
10.1021/jo0484880
15675868
Autor
Garcia, Ariel L L
Carpes, Marcos J S
de Oca, Antonio C B M
dos Santos, Marco A G
Santana, César C
Correia, Carlos Roque D
Institución
Resumen
We report herein a new, practical, and economic synthesis of the phosphodiesterase inhibitor Rolipram on a multigram scale as well as the synthesis of new 4-aryl pyrrolidones and beta-aryl-gamma-amino butyric acids (GABA derivatives) employing an efficient Heck-Matsuda arylation of 3-pyrroline with aryldiazonium tetrafluoroborates. Racemic Rolipram was resolved into its enantiomers using chiral simulated moving bed chromatography having the low-cost microcrystalline cellulose triacetate as a chiral stationary phase. 70 1050-3