Artículos de revistas
T-CELL-DEPENDENT ANTIBODY-RESPONSE TO STAPHYLOCOCCAL-ENTEROTOXIN-B
Registro en:
Scandinavian Journal Of Immunology. Blackwell Science Ltd, v. 42, n. 3, n. 305, n. 310, 1995.
0300-9475
WOS:A1995RR54000003
10.1111/j.1365-3083.1995.tb03660.x
Autor
WILLIAMS, O
AROEIRA, LS
MENGEL, J
Institución
Resumen
Treatment of mice with staphylococcal enterotoxin B (SEB) induces specific T-cell tolerance to this superantigen, characterized by partial deletion of V beta 8(+) T cells in vivo and T cell anergy in vitro. In this study we examined the humoral response to SEB in BALB/c mice. Immunization of mice with SEB results in a detectable anti-SEB antibody response. Upon further treatment of mice with SEB, specific antibody levels increase significantly and the response is accelerated-characteristics of a secondary humoral response. The secondary antibody response is T cell dependent, can be transferred to T cell deficient mice with splenocytes and is composed mainly of IgM, IgGI and IgG2b isotypes, suggesting that Th2 cells provide B cell help in this response. These data demonstrate that at the same time as inducing in vitro unresponsiveness, SEB primes SEB-specific T helper cells to provide help for B cells in a secondary antibody response. 42 3 305 310