Artículos de revistas
MOUSE-LIVER MICROSOMES (MLM) PROTECT ERYTHROCYTES AGAINST TRIFLUOPERAZINE (TFP) INDUCED AND MECHANICAL HEMOLYSIS WHICH ARE DUE TO TFP MICROSOMAL TRANSFORMATION AND TO THE ACTION OF AN UNIDENTIFIED WATER-SOLUBLE MICROSOMAL FACTOR (UF)
Registro en:
European Journal Of Drug Metabolism And Pharmacokinetics. Medecine Et Hygiene, v. 19, n. 4, n. 349, n. 357, 1994.
0378-7966
WOS:A1994QE50000008
Autor
MEIRELLES, NC
MALHEIROS, SVP
RUGGIERO, AC
DEGTEREV, IA
Institución
Resumen
Trifluoperazine (TFP), a phenothiazine derivative, produces either hemolysis or protection of erythrocytes under isosmotic conditions in a dose-dependent manner. The hemolytic effect of TFP is abolished in the presence of mouse liver microsomes (MLM) which is due, in part, to drug incorporation, transformation and a MLM enzyme driven metabolism. An unidentified water-soluble factor (or factors) derived from MLM has been found to protect erythrocytes against both mechanical and TFP-induced isosmotic hemolysis. 19 4 349 357
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Mouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf)
Meirelles N.C.; Malheiros S.V.P.; Ruggiero A.C.; Degterev I.A. -
Mouse Liver Microsomes (mlm) Protect Erythrocytes Against Trifluoperazine (tfp) Induced And Mechanical Hemolysis Which Are Due To Tfp Microsomal Transformation And To The Action Of An Unidentified Water-soluble Microsomal Factor (uf).
Meirelles, N C; Malheiros, S V; Ruggiero, A C; Degterev, I A -
Experimental evidence that endogenous TSH modulates microsomal antigen expression: clinical implications Evidencia experimental que el TSH endogeno modula la expresion del antigeno microsomal: implicancia clinica.
Aguayo,; Valenzuela,; Wohllk,; Pineda, (1993)The purpose of this work was to study if TSH has a role in TPO antigen expression in vivo. Using the cytotoxicity assay we measured TPO expression and correlated it with TSH serum levels in 3 groups of rats: control, ...