Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)This study applies a genetic algorithm embedded with mathematical programming techniques to solve a synchronized and integrated two-level lot sizing and scheduling problem motivated by a real-world problem that arises in soft drink production. The problem considers a production process compounded by raw material preparation/storage and soft drink bottling. The lot sizing and scheduling decisions should be made simultaneously for raw material preparation/storage in tanks and soft drink bottling in several production lines minimizing inventory, shortage and setup costs. The literature provides mixed-integer programming models for this problem, as well as solution methods based on evolutionary algorithms and relax-and-fix approaches. The method applied by this paper uses a new approach which combines a genetic algorithm (GA) with mathematical programming techniques. The GA deals with sequencing decisions for production lots, so that an exact method can solve a simplified linear programming model, responsible for lot sizing decisions. The computational results show that this evolutionary/mathematical programming approach outperforms the literature methods in terms of production costs and run times when applied to a set of real-world problem instances provided by a soft drink company. (C) 2014 Elsevier Ltd. All rights reserved.484052Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)CNPq [483474/2013-4]FAPESP [2010/10133-0]