Artículos de revistas
Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis
Registro en:
Journal Of Natural Products. Amer Chemical Soc, v. 64, n. 10, n. 1278, n. 1281, 2001.
0163-3864
WOS:000171864700004
10.1021/np010211x
Autor
Ito, J
Chang, FR
Wang, HK
Park, YK
Ikegaki, M
Kilgore, N
Lee, KH
Institución
Resumen
A new triterpenoid named melliferone (1), three known triterpenoids, moronic acid (2), anwuweizonic acid (3), and betulonic acid (4), and four known aromatic compounds (5-8) were isolated from Brazilian propolis and tested for anti-HIV activity in H9 lymphocytes. Moronic acid (2) showed significant anti-HIV activity (EC50 <0.1 mug/mL, TI > 186) and was modified to develop more potent anti-AIDS agents. 64 10 1278 1281