Artículos de revistas
Enantioselective total syntheses of ropivacaine and its analogues
Registro en:
Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 49, n. 34, n. 5098, n. 5100, 2008.
0040-4039
WOS:000258271400031
10.1016/j.tetlet.2008.06.028
Autor
Shankaraiah, N
Pilli, RA
Santos, LS
Institución
Resumen
An alternative asymmetric synthesis of ropivacaine and analogues employing the 'cation pool' strategy and host/guest supramolecular co-catalysis approach is presented. In this study, chiral auxiliaries, several soft nucleophiles as well as one-pot conditions for anodic oxidation, followed by nucleophilic addition, have been applied. (c) 2008 Elsevier Ltd. All rights reserved. 49 34 5098 5100