Artículos de revistas
Eicosapentaenoic acid decreases TNF-alpha and protects dystrophic muscles of mdx mice from degeneration
Registro en:
Journal Of Neuroimmunology. Elsevier Science Bv, v. 232, n. 41671, n. 145, n. 150, 2011.
0165-5728
WOS:000289493700019
10.1016/j.jneuroim.2010.10.032
Autor
Machado, RV
Mauricio, AF
Taniguti, APT
Ferretti, R
Neto, HS
Marques, MJ
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) In dystrophin-deficient fibers of mdx mice and in Duchenne muscular dystrophy, inflammation and increased production of tumor necrosis factor alpha (TNF-alpha) contribute to myonecrosis. We examined the effects of eicosapentaenoic acid (EPA) on dystrophic muscle degeneration. Mdx mice (14 days old) received EPA for 16 days. The sternomastoid, diaphragm and biceps brachii muscles were removed. Control mdx mice received vehicle. EPA decreased creatine kinase and myonecrosis and reduced the levels of TNF-alpha. These results suggest that EPA plays a protective role in dystrophic muscle degeneration, possibly by reducing TNF-alpha, and support further investigations of EPA as a potential therapy for dystrophinopathies. (C) 2010 Elsevier B.V. All rights reserved. 232 41671 145 150 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [08/58491-1] CNPq [301386/2007-2, 302006/2009-5]