Artículos de revistas
Concomitant Cisplatin Plus Radiotherapy and High-Dose-Rate Brachytherapy Versus Radiotherapy Alone for Stage IIIB Epidermoid Cervical Cancer: A Randomized Controlled Trial
Registro en:
Journal Of Clinical Oncology. Amer Soc Clinical Oncology, v. 32, n. 6, n. 542, n. 547, 2014.
0732-183X
1527-7755
WOS:000332788900013
10.1200/JCO.2013.50.1205
Autor
Zuliani, AC
Esteves, SCB
Teixeira, LC
Teixeira, JC
de Souza, GA
Sarian, LO
Institución
Resumen
Purpose The benefits of chemoradiotherapy (CRT) for cervical cancer compared with radiation (RT) alone seem to diminish in later-stage disease. However, these modalities have not been directly compared for disease-free interval (DFI) and overall survival (OS) of women with stage IIIB cervical cancer. Patients and Methods We conducted a randomized controlled clinical trial comparing DFI and OS of 147 women with stage IIIB squamous cervical cancer who received either cisplatin plus RT (CRT) or RT alone (72 patients in the CRT group and 75 patients in the RT-only group). Results The CRT group had significantly better DFI (hazard ratio [HR], 0.52; 95% CI, 0.29 to 0.93; P = .02). However, patients in the CRT group did not have significantly better OS than those in the RT-only group (HR, 0.67; 95% CI, 0.38 to 1.17; P = .16). Toxicity was graded according to criteria of the Radiation Therapy Oncology Group. The organs affected (excluding hematologic effects) did not differ significantly between groups. Also, late toxicity events and organs affected were not significantly disproportionate between the study groups. Conclusion For stage IIIB cervical cancer, the addition of cisplatin offers a small but significant benefit in DFI, with acceptable toxicity. (C) 2014 by American Society of Clinical Oncology 32 6 542 547