Artículos de revistas
Biotechnological Production Of Bioflavors And Functional Sugars [produção Biotecnológica De Bioaromas E Açúcares Funcionais]
Registro en:
Ciencia E Tecnologia De Alimentos. , v. 30, n. 1, p. 7 - 18, 2010.
1012061
2-s2.0-77952938427
Autor
Bicas J.L.
Silva J.C.
Dionisio A.P.
Pastore G.M.
Institución
Resumen
Bioflavors and oligosaccharides are two classes of substances that may be produced biotechnologically through microbial bioprocesses. These compounds have attracted the interest of pharmaceutical and food industries not only due to their technological properties (sweetening/ fiber or flavoring, respectively), but also as a consequence of other functional properties such as, for example, health promoting benefits. The use of agro-industrial residues as substrates in biotechnological processes seems to be a valuable alternative in helping to overcome the high manufacturing costs of industrial fermentations. This manuscript reviews the most important advances in biotechnological production of bioflavors and oligosaccharides. The use of some agro-industrial residues in such processes is also cited and discussed, showing that this is a rising trend in biotechnology. 30 1 7 18 Adams, A., Demyttenaere, J.C.R., de Kimpe, N., Biotransformation of (r)-(+)- and (S)-(-)-limonene to Alpha-terpineol by Penicillium digitatum - Investigation of the Culture Conditions (2003) Food Chemistry, 80 (4), pp. 525-534 Albayrak, N., Yang, S.T., Production of Galacto-oligosaccharides from Lactose by Aspergillus oryzae β-Galactosidase Immobilized in Cotton Cloth (2002) Biotechnology and Bioengineering, 77 (1), pp. 8-19 Armstrong, D.W., Martin, S.M., Yamazaki, H., Production of ethyl acetate from dilute ethanol solutions by Candida utilis (1984) Biotechnology and Bioengineering, 26 (9), pp. 1038-1041 Aslan, Y., Tanriseven, A., Immobilization of Pectinex Ultra SP-L to produce galactooligosaccharides (2007) Journal of Molecular Catalysis B: Enzymatic, 45, pp. 73-77 Assaf, S., Hadar, Y., Dosoretz, C., G. 1-octen-3-ol and 13-hydroperoxylinoleate are products of distinct pathways in the oxidative breakdown of linoleic acid by Pleurotus pulmonarius (1997) Enzyme and Microbial Technology, 21 (7), pp. 484-490 Bauer, K., Garbe, D., Surburg, H., (2001) Common Fragrance and Flavor Materials: Preparation, Properties and Uses, p. 293. , 4th ed. Weinheim: Wiley - vCH Berger, R.G., Biotechnology of flavours - the next generation (2009) Biotechnology Letters, V, 11, p. 31 Bicas, J.L., Integrated process for co-production of alkaline lipase and r-(+)-α-terpineol by Fusarium oxysporum (2010) Food Chemistry, 120 (2), pp. 452-456 Bicas, J.L., Optimization of r-(+)-α-terpineol Production by the Biotransformation of r-(+)-Limonene (2008) Journal of Industrial Microbiology and Biotechnology, 35 (9), pp. 1061-1070 Bicas, J.L., A bioprocess for the production of high concentrations of r-(+)-α-terpineol from r-(+)-limonene (2009) Process Biochemistry, , In press. DoI:10.1016/j.procbio, 11.007 Bicas, J.L., Characterization of Monoterpene Biotransformation in Two Pseudomonads (2008) Journal of Applied Microbiology, 105, pp. 1991-2001 Bicas, J.L., Dionisio, A.P., Pastore, G.M., Bio-oxidation of terpenes: An approach to Flavor industry (2009) Chemical Reviews, 109 (9), pp. 4518-4531 Bluemke, W., Schraderb, J., Integrated bioprocess for enhanced production of natural flavors and fragrances by Ceratocystis moniliformis (2001) Biomolecular Engineering, 17 (4-5), pp. 137-142 Bramorski, A., Production of volatile compounds by the edible fungus Rhizopus oryzae during solid-state cultivation on tropical agro-industrial substrates (1998) Biotechnology Letters, 20 (4), pp. 359-362 Bramorski, A., Fruit aroma production by Ceratocystis fimbriata in static cultures from solid agro-industrial wastes (1998) Revista De Microbiologia, 28 (3), pp. 208-212 Cadwallader, K.R., Bioconversion of (+)-Limonene by Pseudomonas gladioli (1989) Journal of Food Science, 54 (5), pp. 1241-1245 Cadwallader, K.R., Braddock, R.J., Parish, M.E., Isolation of α-Terpineol Dehydratase from Pseudomonas gladioli (1992) Journal of Food Science, 57 (1), pp. 241-244 Chambert, R., Gonzy-Tréboul, G., Levansucrase of Bacillus subtilis: Kinetic and Thermodynamic Aspects of Transfructosylation Processes (1976) European Journal of Biochemistry, 62, pp. 55-64 Chambert, R., Treboul, G., Dedonder, R., Kinetic Studies of Levansucrase of Bacillus subtilis (1974) European Journal of Biochemistry, 41, pp. 285-300 Cho, Y.J., Shin, H.J., Bucke, C., Purification and biochemical properties of a galactooligosaccharide producing β-Galactosidase from Bullera singularis (2003) Biotechnology Letters, 25 (24), pp. 2107-2111 Chockchaisawasdee, S., Synthesis of Galacto-oligosaccharide From Lactose Using β-Galactosidase From Kluyveromyces lactis: Studies on Batch and Continuous UF Membrane-Fitted Bioreactors (2004) Biotechnology and Bioengineering, 89 (4), pp. 434-443 Christen, P., Caracterization of volatile compounds produced by Rhyzopus strains grown on agro-industrial solid wastes (2000) Bioresource Technology, 71 (3), pp. 211-215 Christen, P., Meza, J.C., Revah, S., Fruity aroma production in solid state fermentation by Ceratocystis fimbriata: Influence of the substrate type and the presence of precursors (1997) Mycological Research, 101 (8), pp. 911-919 Collins, R.P., Halim, A.F., Essential oil composition of Ceratocystis virescens (1977) Mycologia, 69 (6), pp. 1129-1136 Committee on Bioprocess engineering (1992) Putting Biotechnology to Work: Bioprocess Engineering, p. 120. , The National research Council, Wasington, D.C.: National Academy of Sciences Crittenden, R.G., Prebiotics (1999) Probiotics: A Critical Review, pp. 141-156. , In: TANNoCK, G. W. (ed.), Wymondham: Horizon Scientific Press Crowell, P., Prevention and therapy of cancer by dietary monoterpenes (1999) Journal of Nutrition, 129 (3), pp. 775S-778S Cruz, R., Production of fructooligosaccharides by the mycelia of Aspergillus japonicus immobilized in calcium alginate (1998) Bioresource Technology, 65 (1-2), pp. 139-143 Cruz, R., Production of transgalactosylated oligosaccharides (ToS) by galactosyltransferase activity from Penicillium simplicissimum (1999) Bioresource Technology, 70, pp. 165-171 Cummings, J.H., A new look at dietary carbohydrate: Chemistry, physiology and health (1997) European Journal of Clinical Nutrition, 51 (7), pp. 417-423 Damasceno, S., Production of volatile compounds by Geotrichum fragrans using cassava wastewater as substrate (2003) Process Biochemistry, 39 (4), pp. 411-414 Daugsch, A., Pastore, G.M., Obtenção de vanilina: Oportunidade biotecnológica (2005) Química Nova, 28 (4), pp. 642-645 de Carvalho, C.C.C.R., da Fonseca, M.M.R., Carvone: Why and how should one bother to produce this terpene (2006) Food Chemistry, 95 (3), pp. 413-422 Delzenne, N.M., Oligosaccharides: State of the art (2003) Proceedings of The Nutrition Society, 62 (1), pp. 177-182 Demain, A.L., Jackson, M., Trenner, N.R., Thiamine-dependent Accumulation of Tetramethylpyrazine Accompanying a Mutation in the Isoleucine-valine Pathway (1967) Journal of Bacteriology, 94 (2), pp. 323-326 Demyttenaere, J.C.R., Biotransformation of Terpenoids by Microorganisms (2001) Studies In Natural Products Chemistry, pp. 125-178. , In: rAHMAN, A. (ed.), London: elsevier Demyttenaere, J.C.R., van Belleghem, K., de Kimpe, N., Biotransformation of (r)-(+)- and (S)-(-)-Limonene by Fungi and the Use of Solid Phase Microextraction for Screening (2001) Phytochemistry, 57 (2), pp. 199-208 di Gioia, D., Production of biovanillin from wheat bran (2007) Enzyme and Microbial Technology, 41 (4), pp. 498-505 Doble, M., Kruthiventi, A.K., Gaikar, V.G., (2004) Biotransformation and Bioprocesses, , New York: Marcel Dekker Inc Dorta, C., Sugarcane molasses and yeast powder used in the Fructooligosaccharides production by Aspergillus japonicus-FCL 119T and Aspergillus niger ATCC 20611 (2006) Journal of Industrial Microbiology and Biotechnology, 33 (12), pp. 1003-1009 Fernández, R.C., Production of fructooligosccharides by β-frutofuranosidase from Aspergillus sp. 27H (2004) Journal of Chemical Technology and Biotechnology, 79, pp. 268-272 Foda, M.I., Lópezleiva, M., Continuous production of oligosaccharides from whey using a membrane reactor (2000) Process Biochemistry, 35 (6), pp. 581-587 Francke, W., Brummer, G., Terpene aus Ascoidea hylecoeti (1978) Planta Medica, 34, pp. 426-429 Franco, M.R.B., (2004) Aroma E Sabor Dos Alimentos: Temas Atuais, p. 246. , São Paulo: Livraria varela Gatfield, I.L., Production of flavor and aroma compounds by biotechnology (1988) Food Technology, 42 (10), pp. 110-169 Gaur, R., Galacto-oligosaccharide synthesis by immobilized Aspergillus oryzae β-galactosidase (2006) Food Chemistry, 97 (3), pp. 426-430 Ghazi, I., Beet sugar syrup and molasses as low-cost feedstock for the enzymatic production of fructo-oligosaccharides (2006) Journal of Agricultural and Food Chemistry, 54 (8), pp. 2964-2968 Goulas, A., Tzortzis, G., Gibson, G.R., Development of a process for the production and purification of α- and β-galactooligosaccharides from Bifidobacterium bifidum NCIMB 41171 (2007) International Dairy Journal, 17, pp. 648-656 Hartemink, R., Vanlaere, K.M.J., Rombouts, F.M., Growth of enterobacteria on fructo-oligosaccharides (1997) Journal of Applied Microbiology, 83 (3), pp. 367-374 Hayashi, S., Yoshiyama, T., Fujii, N., Production of a novel syrup containing neofructo-oligosaccharides by the cells of Penicillium citrinum (2000) Biotechnology Letters, 22 (18), pp. 1465-1469 Hettwer, U., Gross, M., Rudolph, K., Purification and Characterization of an extracellular Levansucrase from Pseudomonas syringae pv. phaseolicola (1995) Journal of Bacteriology, 177 (10), pp. 2834-2839 Hölker, U., Lenz, J., Solid-state fermentation - are there any biotechnological advantages? (2005) Current Opinion In Microbiology, 8 (3), pp. 301-306 Hubball, J.A., Collinds, R.P., A study of factor affecting the synthesis of terpenes by ceratocystis variospora (1978) Mycologia, 70 (1), pp. 117-129 Janssens, L., Production of flavours by microorganisms (1992) Process Biochemistry, 27 (4), pp. 195-215 Kaufhold, J., Hammon, H.M., Blum, J.W., Fructooligosaccharide supplementation: Effects on metabolic, endocrine and hematological traits in veal calves (2000) Journal of Veterinary Medicine, Animal Physiology, Pathology and Clinical Medicine, 47 (1), pp. 17-29 Kim, B.W., Kwon, H.J., Park, H.Y., Production of a novel transfructosylating enzyme from Bacillus macerans eG-6 (2000) Bioprocess Engineering, 23 (1), pp. 11-16 Kim, S.K., Rajapakse, N., Enzymatic production and biological activities of chitosan oligosaccharides (CoS): A review (2005) Carbohydrates Polymers, 62 (4), pp. 357-368 Kim, Y.S., Park, C.S., Oh, D.K., Lactulose production from lactose and fructose by a thermostable β-galactosidase from Sulfolobus solfataricus (2006) Enzyme and Microbial Technology, 39, pp. 903-908 Kosuge, T., Kamiya, H., Discovery of a Pyrazine in a Natural Product (1962) Tetramethylpyrazine From Cultures of A Strain of Bacillus Subtilis. Nature, 193 (4817), p. 776 Kraidman, G., Mukherjee, B.B., Hill, J.D., Conversion of D-Limonene into an optically Active Isomer of α-Terpineol by a Cladosporium Species (1969) Bacteriological Proceedings, 69, p. 63 Lanza, E., Ko, K.H., Palmer, J.K., Aroma production by cultures of Ceratocystis moniliformis (1976) Journal of Agricultural and Food Chemistry, 24 (6), pp. 1247-1250 Laseter, J.L., Weete, J.D., Walkinshaw, C., H. volatile terpenoids from aeciospores of Cronartium fusiforme (1973) Phytochemistry, 12, pp. 387-390 Lesagemeessen, L., Biotechnological process involving filamentous fungi to produce natural crystalline vanillin from maize bran (2002) Applied Biochemistry and Biotechnology, 102-103 (1-6), pp. 141-153 Lim, J.S., Studies on production and physical properties of neo- FoS produced by co-immobilized Penicillium citrinum and neo- fructosyltransferase (2007) European Food Research and Technology, 225 (3-4), pp. 457-462 Longo, M.A., Sanromán, M.A., Production of food aroma compounds: Microbial and enzymatic methodologies (2006) Food Technological Biotechnological, 44 (3), pp. 335-353 López-Leiva, M., Guzman, M., Formation of oligosaccharides during enzymic hydrolysis of milk whey permeates (1995) Process Biochemistry, 30 (8), pp. 757-762 Maaleja-Chouri, I., Production of xylo-oligosaccharides from agro-industrial residues using immobilized Talaromyces thermophilus xylanase (2009) Journal of Molecular Catalysis B: Enzymatic, 59 (1-3), pp. 145-152 Makkar, R.S., Cameotra, S.S., An update on the use of unconventional substrates for biosurfactant production and their new applications (2002) Applied Microbiololy Biotechnology, 58 (4), pp. 428-434 Maróstica Jr., M.R., Pastore, G.M., Biotransformation of citronellol in rose-oxide using cassava wastewater as a medium (2006) Ciência E Tecnologia De Alimentos, 26 (3), pp. 690-696 Maróstica Jr., M.R., Pastore, G.M., Production of r-(+)- α-terpineol by the biotransformation of limonene from orange essential oil, using cassava waste water as medium (2007) Food Chemistry, 101 (1), pp. 345-350 Maróstica Jr., M.R., Fungal biotransformation of monoterpenes found in agro-industrial residues from orange and pulp industries into aroma compounds: Screening using solid phase microextraction (2007) Food Science and Biotechnology, 16 (1), pp. 37-42 Maróstica Jr., M.R., Pastore, G.M., Biotransformation of Limonene: A review of the Main Metabolic Pathways (2007) Química Nova, 30 (2), pp. 382-387 Marques, D.B., Pastore, G.M., Produção de aromas naturais por microrganismos (1999) Boletim SBCTA, 33 (1), pp. 80-85 Martínez-Fleites, C., Ortízlom-Bardía, M., Pons, T., Crystal structure of levansucrase from the Gram-negative bacterium Gluconacetobacter diazotrophicus (2005) The Biochemical Journal, 390 (1), pp. 19-27 Matsumoto, K., Kobayashi, Y., Tamura, N., Production of Galactooligosaccharides with β-Galactosidase (1989) Denpun Kagaku, 36, pp. 123-130 Medeiros, A.B.P., Optimization of the production of aroma compounds by Kluyveromyces marxianus in solid-state fermentation using factorial design and response surface methodology (2000) Biochemical Engineering Journal, 6 (1), pp. 33-39 Molis, C., Digestion, excretion, and energy value of fructooligosaccharides in healthy humans (1996) The American Journal of Clinical Nutrition, 64 (3), pp. 324-328 Monsan, P., Paul, F., Enzymatic synthesis of oligosaccharides (1995) FEMS Microbiology Reviews, 16 (2-3), pp. 187-192 Muheim, A., Microbiological process for producing vanillin (2001) United States Patent 6,235,507, , May 22th Mussato, S.I., Aguilar, C.N., Rodrigues, L.R., Fructooligosaccharides and β-fructofuranosidase production by Aspergillus japonicus immobilized on lignocellulosic materials (2009) Journal of Molecular Catalysis B: Enzymatic, 59 (1-3), pp. 76-81 Neri, D.F.M., Galacto-oligosaccharides production during lactose hydrolysis by free Aspergillus oryzae β-galactosidase and immobilized on magnetic polysiloxane-polyvinyl alcohol (2009) Food Chemistry, 115 (1), pp. 92-99 Onishi, N., Tanaka, T., Purification and Properties of a Novel Thermostable Galacto-oligosaccharide-Producing β-Galactosidase from Sterigmatomyces elviae CBS8119 (1995) Applied and Environmental Microbiology, 61 (11), pp. 4026-4030 Orzua, M.C., Exploitation of agro industrial wastes as immobilization carrier for solid-state fermentation (2009) Industrial Crops and Products, 30 (1), pp. 24-27 Ozimek, L.K., Kralj, S., van der Maarel, M.J.E.C., The levansucrase and inulosucrase enzymes of Lactobacillus reuteri 121 catalyse processive and non-processive transglycosylation reactions (2006) Microbiology, 152 (4), pp. 1187-1196 Pandey, A., Solid-state fermentation (2003) Biochemical Engineering Journal, 13 (2-3), pp. 81-84 Pandey, A., New developments in solid state fermentation: I-bioprocesses and products (2000) Process Biochemistry, 35 (10), pp. 1153-1169 Pandey, A., Biotechnological potential of agro-industrial residues. II: Cassava bagasse (2000) Bioresource Technology, 74 (1), pp. 81-87 Pandey, A., Biotechnological potential of coffee pulp and coffee husk for bioprocesses (2000) Biochemical Engineering Journal, 6 (2), pp. 153-162 Pandey, A., Biotechnological potential of agro-industrial residues. I: Sugarcane bagasse (2000) Bioresource Technology, 74 (1), pp. 69-80 Park, Y.K., Almeida, M.M., Production of fructooligosaccharides from sucrose by a transfructosylase from Aspergillus niger (1991) World Journal of Microbiology and Biotechnology, 7 (3), pp. 331-334 Park, Y.K., Pastore, G.M., Process for preparing beta- fructofuranosidase enzyme and a process for producing fructooligosaccharides. United States Patent 7,063,976 (2006) June 20th Park, Y.C., Shaffer, C.E.H., Bennett, G.N., Microbial formation of esters (2009) Applied Microbiology and Biotechnology, V, 1, p. 85 Pastore, G.M., Park, Y.K., Min, D.B., Production of fruity aroma by Neurospora from beiju (1994) Mycological Research, 98 (11), pp. 1300-1302 Pastore, G.M., Park, Y.K., Min, D.B., Production of fruity aroma by Neurospora species isolated from Beiju (1995) Revista De Microbiologia, 26 (1), pp. 55-58 Pescheck, M., Improved monoterpene biotransformation with Penicillium sp. by use of a closed gas loop bioreactor (2009) Journal of Industrial Microbiology and Biotechnology, 36 (6), pp. 827-836 Prenosil, J.E., Stucker, E., Bourne, J.R., Formation of oligosaccharides during enzymatic lactose hydrolysis and their importance in a whey hydrolysis process (1987) Part II: Experimental. Biotecnology and Bioengineering, 30 (9), pp. 1019-1025 Rabenhorst, J., Hopp, R., Process for the preparation of vanillin and microorganisms suitable therefore (2000) United States Patent 6,133,003, , October 17th Roberfroid, M.B., Slavin, J., Non digestible oligosaccharides (2000) Critical Reviews In Food Science and Nutrition, 40 (60), pp. 461-480 Rossi, S.C., Improving fruity aroma production by fungi in SSF using citric pulp (2009) Food Research International, 42 (4), pp. 484-486 Roy, D., Daoudi, L., Azaola, A., Optimization of galactooligosaccharide production by Bifidobacterium infantis rW-8120 using response surface methodology (2002) Journal of Industrial Microbiology and Biotechnology, 29, pp. 281-285 Rustom, I.Y.S., Foda, M.I., Lópezleiva, M.H., Formation of oligosaccharides from whey UF-permeate by enzymatic hydrolysis - analysis of factors (1998) Food Chemistry, 62 (2), pp. 141-147 Sako, T., Matsumoto, K., Tanaka, R., Recent progress on research and applications of non-digestible galacto-oligosaccharides (1999) International Dairy Journal, 9 (1), pp. 69-80 Sangeetha, P.T., Ramesh, M.N., Prapulla, S.G., Fructooligosaccharide production using fructosyl transferase obtained from recycling culture of Aspergillus oryzae CFr 202 (2005) Process Biochemistry, 40 (3-4), pp. 1085-1088 Sangeetha, P.T., Ramesh, M.N., Prapulla, S.G., Production of fructo-oligosaccharides by fructosyl transferase from Aspergillus oryzae CFr 202 and Aureobasidium pullulans CFr 77 (2004) Process Biochemistry, 39 (6), pp. 755-760 Sangeetha, P.T., Ramesh, M.N., Prapulla, S.G., Production of fructosyl transferase by Aspergillus oryzae CrF 202 in solid-state fermentation using agricultural by-products (2004) Applied Microbiology and Biotechnology, 65, pp. 530-537 Sangeetha, P.T., Ramesh, M.N., Prapulla, S., G. recent trends in microbial production, analysis and application of Fructooligosaccharides (2005) Food Science and Technology, 16 (10), pp. 442-457 Santos, A.M.P., Maugeri, F., Synthesis of fructooligosaccharides from sucrose using inulinase from Klyveromyces marxianus (2007) Food Technology and Biotechnology, 45 (2), pp. 181-186 Savithiry, N., Cheong, T.K., Oriel, P., Production of Alpha-Terpienol from Escherichia coli Cells expressing Thermostable Limonene Hydratase (1997) Applied Biochemistry and Biotechnology, 63, pp. 213-220 Sheu, D.C., Production of galactooligosaccharides by β-galactosidase immobilized on glutaraldehyde-treated chitosan beads (1998) Biotechnology Techniques, 12 (4), pp. 273-276 Shin, H.J., Park, J.M., Yang, J.W., Continuous production of galacto-oligosaccharides from lactose by Bullera singularis β-galactosidase immobilized in chitosan beads (1998) Process Biochemistry, 33 (8), pp. 787-792 Shin, H.T., Production of fructo-oligosaccharides from molasses by Aureobasidium pullulans cells (2004) Bioresource Technology, 93 (1), pp. 59-62 Singhania, R.R., Recent advances in solid-state fermentation (2009) Biochemical Engineering Journal, 44 (1), pp. 13-18 Sloan, A.E., The top 10 functional food trends: The next generation (2002) Food Technology, 56 (4), pp. 32-35 Soares, M., Christen, P., Pandey, A., Fruit flavor production by Ceratocystis fimbriata grown on coffe husk in solid-state fermentation (2000) Process Biochemistry, 35, pp. 857-861 Song, D.D., Jacques, N.A., Purification and enzymic properties of the fructosyltransferase of Streptococcus salivarius ATCC 25975 (1999) The Biochemical Journal, 341 (2), pp. 285-291 Spiegel, J.E., Rose, R., Karabell, P., Safety and benefits of frutooligosaccharides as food ingredients (1994) Food Technology, 48 (1), pp. 85-89 Támbara, Y., Hormaza, J.V., Pérez, C., Structural analysis and optimized production of fructo-oligosaccharides by levansucrase from Acetobacter diazotrophicus STr4 (1999) Biotechnology Letters, 21, pp. 117-121 Tan, Q., Day, D.F., Bioconversion of Limonene to α-Terpineol by Immobilized Penicillium digitatum (1998) Applied Microbiology and Biotechnology, 49 (1), pp. 96-101 Tan, Q., Day, D., F. organic Co-solvent effects on the Bioconversion of (r)-(+)-Limonene to (r)-(+)-α-Terpineol (1998) Process Biochemistry, 33 (7), pp. 755-761 Tan, Q., Day, D.F., Cadwallader, K.R., Bioconversion of (r)-(+)-Limonene by P. digitatum (NrrL 1202) (1998) Process Biochemistry, 33 (1), pp. 29-37 Thibault, J.F., Fungal bioconversion of agricultural by-products to vanillin (1998) Lebensmittel-Wissenschaft Und-Technologie, 31 (6), pp. 530-536 Tomomatsu, H., Health effects of oligosaccharides (1994) Food Technology, 48 (10), pp. 61-65 Torres, B.R., Vanillin bioproduction from alkaline hydrolyzate of corn cob by Escherichia coli JM109/pBB1 (2009) Enzyme and Microbial Technology, 44 (3), pp. 154-158 van Hijum, S.A.F.T., Szalowska, E., van der Maarel, M.J.E.C., Biochemical and molecular characterization of a levansucrase from Lactobacillus reuteri (2004) Microbiology, 150 (3), pp. 621-630 Walton, N.J., Novel approaches to the biosynthesis of vanillin (2000) Current Opinion In Biotechnology, 11 (5), pp. 490-496 Wang, L., Yang, S.T., Solid State Fermentation and its applications (2007) Bioprocessing For Value-added Products From Renewable Resources. Amsterdam: Elsevier, pp. 465-489. , In: YANG, S. T. (ed.) Welsh, F.W., Murray, W.D., Williams, R.E., Microbiological and enzymatic production of flavor and fragrance chemicals (1989) Critical Reviews In Biotechnology, 9 (2), pp. 105-169 Yamashita, K., Kawai, K., Itakamura, M., Effects of fructooligosaccharides on blood-glucose and serum lipids in diabetic subjects (1984) Nutrition Research, 4 (6), pp. 961-966 Yamauch, H., Production of characteristic odors by Neurospora (1991) Agricultural and Biological Chemistry, 55 (12), pp. 3115-3116 Yamauchi, H., Hasuo, T., Amachi, T., Purification and Characterization of Acyl Coenzyme A (1989) Alcohol Acyltransferase of Neurospora Sp. Agricultural and Biological Chemistry, 53 (6), pp. 1551-1556 Yoshizawa, K., Production of a fruity odor by Neurospora sp (1988) Agricultural and Biological Chemistry, 52 (8), pp. 2129-2130 Yun, J.W., Fructooligosaccharides - ocurrence, preparation and application (1996) Enzyme and Microbial Technology, 19 (2), pp. 107-117 Yun, J.W., Song, S.K., The production of high-content fructo-oligosaccharides from sucrose by the mixed-enzyme system of fructosyltranferase and glucose oxidase (1993) Biotechnology Letters, 15 (6), pp. 573-576 Zheng, L., Production of vanillin from waste residue of rice bran oil by Aspergillus niger and Pycnoporus cinnabarinus (2007) Bioresource Technology, 98 (5), pp. 1115-1119