Behçet's disease (BD) is a chronic, relapsing, systemic vasculitis of unknown etiology with the clinical features of mucocutaneous lesions, ocular, vascular, articular, gastrointestinal, urogenital, pulmonary, and neurologic involvement. It is believed to be due to an auto-immune process triggered by an infectious or environmental agent in a genetically predisposed individual. HLA-B51 is the most strongly associated risk factor. The disease usually starts around the third decade of life. Mucocutaneous lesions figure prominently in the presentation and diagnosis, and may be considered the hallmarks of BD. Therefore, their recognition may permit earlier diagnosis and treatment. Although, the treatment has become much more effective in recent years, BD is still associated with severe morbidity and considerable mortality. The main aim of the treatment should be the prevention of irreversible organ damage. Therefore, close monitoring, early and appropriate treatment is mandatory to reduce morbidity and mortality. We will review symptoms, diagnosis and the current state of knowledge regarding the therapeutic approaches for BD. © 2011 Nova Science Publishers, Inc. All rights reserved. 229248Sakane, T., Takeno, M., Suzuki, N., Inaba, G., Behçet's disease (1999) N Engl J Med., 341, pp. 1284-1291Correia, M., Barbedo, M., Vaio, T., Mota, M., Gonçalves, O., Valente, J., Behçet's disease-a contemporary review (2009) Journal of Autoimmunity., 32, pp. 178-188Yurdakul, S., Hamuryudan, V., Yazici, H., Behçet's syndrome (2003) Curr Opin Rheumatol., 16, pp. 38-42Evereklioglu, C., Current concepts in the etiology and treatment of Behçets disease (2005) Surv Ophthalmol., 50, pp. 297-350Sut, N., Seyahi, E., Yurdakul, S., Senocak, M., Yazici, H., A cost analysis of Behçet's syndrome in Turkey (2007) Rheumatology., 46, pp. 678-682Kulaber, A., Tugal-Tutkun, I., Sibel, P., Pro-inflammatory cellular immune response in Behçet's disease (2007) RheumatolInt., 27, pp. 1113-1118Ahmad, T., Wallace, G.R., James, T., Neville, M., Mapping the HLA association in Behçet's disease a role for tumor necrosis factor polymorphisms? (2003) Arthritis Rheum., 48, pp. 807-813Akman, A., Sallakci, N., Kacaroglu, H., Relationship between periodontal findings and the TNF-alpha Gene 1031T/C polymorphism in Turkish patients with Behçet's disease (2008) J Eur Acad Dermatol Venereol., 22, pp. 950-957Verity, D.H., Marr, J.E., Ohno, S., Behçet's diseasethe Silk Road and HLA-B51, historical and geographical perspectives (1999) Tissue Antigens., 54, pp. 213-220Kazi, S., Behçet's disease (2004) Encyclopedia of Gastroenterology., 3, pp. 169-171Tugal-Tutkun, I., Onal, S., Altan-Yaycioglu, R., Uveitis in Behcet disease: an analysis of 880 patients (2004) Am J Ophthalmol., 138, pp. 373-380Tursen, U., Gurler, A., Boyvat, A., Evaluation of clinical findings according to sex in 2313 Turkish patients with Behcet's disease (2003) Int J Dermatol., 42, pp. 346-351Zouboulis, C.C., Epidemiology of Adamantiades-Behçet's disease (1999) Ann Med Interne., 150, pp. 488-498Zouboulis, C.C., Kotter, I., Djawari, D., Epidemiological features of Adamantiades-Behcet's disease in Germany and in Europe (1997) Yonsei Med J., 38, pp. 411-422Oshima, Y., Shimizu, T., Yokohari, R., Clinical studies on Behçet's syndrome (1963) Ann Rheum Dis., 22, pp. 36-45Yazici, H., TüZün, Y., Pazarli, H., Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome (1984) Ann Rheum Dis., 43, pp. 783-789Tsai, J., Chen, G.S., Lu, Y.W., Wu, C.S., Lan, C.C., Late-onset Behçet's disease does not correlate with indolent clinical course: report of seven Taiwanese patients (2008) J Eur Acad Dermatol Venereol., 22, pp. 596-600Saricaoglu, H., Karadogan, K.S., Bayzazit, N., Clinical features of late-onset Behçet's disease: report of nine cases (2006) Int J Dermatol., 45, pp. 1284-1287Pay, S., Simsek, I., Erdem, H., Dinç, A., Immunopathogenesis of Behçet's disease with special emphasize to the possible role of antigen presenting cells (2007) Rheumatol Int., 27, pp. 417-424Dundar, S.V., Gencalp, U., Simsek, H., Familial cases of Behçet's disease (1985) Br J Dermatol., 113, pp. 319-321Arber, N., Klein, T., Meiner, Z., Pras, E., Weinberger, A., Close association of HLA-B51 and B52 in Israeli patients with Behçet's syndrome (1991) Ann Rheum Dis., 50, pp. 351-353Akpolat, T., Koc, Y., Yeniay, I., Akpek, G., Gullu, I., Kansu, E., Familial Behçet's disease (1992) European Journal of Medicine., 1, pp. 391-395Nishiura, K., Kotake, S., Ichiishi, A., Matsuda, H., Familial occurrence of Behçet's disease (1996) Jpn J Ophthalmol., 40, pp. 255-259Nishiyama, M., Nakae, K., Hashimoto, T., Inaba, G., Sakane, T., Recent epidemiological features of familial Behçet's disease in Japan (1996) Asian Medical Journal., 39, pp. 495-501Shahram, F., Chams, C., Davatchi, F., Dadji, A., Akbarian, M., Jamshidi, A., Familial study in Behçet's diseaseanalysis of 1242 patients. 8th International Congress on Behçet's disease. October 7-9, 1998 (1998) Reggio EmiliaItaly;., P9, p. 103Fresko, I., Soy, M., Hamuryudan, V., Yurdakul, S., Yavuz, S., Tumer, Z., Genetic anticipation in Behçet's syndrome (1998) Ann Rheum Dis., 57, pp. 45-48Yazici, H., Çiçek, B., Basaran, G., Hamuryudan, V., Cakir, N., Dimitriatris, I., Behçet'ssyndrome with emphasis on clinical genetics and mortality London: (1996) Chapman and Hall., pp. 199-206. , In: Ansell BMBacon PALie JTYazici Heds. The vasculitidesKoné-Paut, I., Geisler, I., Wechsler, B., Ozen, S., Ozdogan, H., Rozenbaum, M., Familial aggregation in Behçet's disease: high frequency in siblings and parents of pediatric probands (1999) J Pediatr., 135, pp. 89-93Aral, O., Dilsen, N., Konice, M., Positive skin pathergy reactivity as a genetic marker of Behçet'sdisease (1986) Royal Society of Medicine Services;., pp. 173-175. , In: Lehner TBarnes CGeds. Recent advances in Behçet'sdisease. London:Chamberlain, M.A., A family study of Behcet's syndrome (1978) Ann Rheum Dis., 37, pp. 459-465Bird Stewart, J.A., Genetic analysis of families of patients with Behçet's syndrome: data incompatible with autosomal recessive inheritance (1986) Ann Rheum Dis., 45, pp. 265-268Guo, S.W., Inflation of sibling recurrence risk-ratiodue to ascertainment bias and/or overreporting (1998) Am J Hum Genet., 63, pp. 252-258Gü, L.A., Inanç, M., Öcal, L., Aral, L., Koniçe, M., Familial aggregation of Behçet's disease in Turkey (2000) Ann Rheum Dis., 59, pp. 622-625Coskun, M., Bacanli, A., Sallakci, N., Alpsoy, E., Yavuzer, U., Yegin, O., Specific interleukin-1 gene polymorphisms in Turkish patients with Behçet's disease (2005) Exp Dermatol., 14, pp. 124-129Karasneh, J., Hajeer, A.H., Barrett, J., Oliver, W.E., Thornhill, M., Gu, L.A., Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behçet'sdisease (2003) Rheumatology., 42, pp. 860-864Boiardi, L., Salvarani, C., Casali, B., Olivieri, I., Ciancio, G., Cantini, F., Intercellular adhesion molecule-1 gene polymorphisms in Behçet'sdisease (2001) J Rheumatol., 28, pp. 1283-1287Verity, D.H., Vaughan, R.W., Kondeatis, E., Madanat, W., Zureikat, H., Fayyard, F., Intercellular adhesion molecule-1 gene polymorphism in Behçet's disease (2000) Eur J Immunogenet., 27, pp. 73-76Salvarani, C., Boiardi, L., Casali, B., Olivieri, I., Ciancio, G., Cantini, F., Endothelial nitric oxide synthase gene polymorphisms in Behçet'sdisease (2002) J Rheumatol., 29, pp. 535-540Ayesh, S., Abu-Rmaileh, H., Nassar, S., Molecular analysis of MEFV gene mutations among Palestinian patients with Behçet'sdisease (2008) Scand J Rheumatol., 37, pp. 370-374Rabinovich, E., Shinar, Y., Leiba, M., Ehrenfeld, M., Langewitz, P., Livneh, A., Common FMF alleles may predispose to development of Behçet's disease with increased risk for venous thrombosis (2007) Scand J Rheumatol., 36, pp. 48-52Imirzalioglu, N., Dursun, A., Tastan, B., Soysal, Y., Yakicier, M.C., MEFV gene is a probable susceptibility gene for Behçet's disease (2005) Scand J Rheumatol., 34, pp. 56-58Lehner, T., The role of heat shock proteinmicrobial and autoimmune agents in the aetiology of Behçet's disease (1997) Int Rev Immunol., 14, pp. 21-32Direskeneli, H., Behçet's disease: infectious aetiologynew autoantigensand HLA-B51 (2001) Ann Rheum Dis., 60, pp. 996-1002Ergun, T., Ince, U., Eksioglu-Demiralp, E., HSP 60 expression in mucocutaneous lesions of Behçet's disease (2001) J Am Acad Dermatol., 45, pp. 904-909Musabak, U., Pay, S., Erdem, H., Simsek, I., Pekel, A., Dinc, A., Serum interleukin-18 levels in patients with Behçet's disease. Is its expression associated with disease activity or clinical presentations? (2006) Rheumatol Int., 26, pp. 545-550Hamzaoui, K., Hamzaoui, A., Ghorbel, I., Khanfir, M., Houman, H., Levels of IL-15 in serum and cerebrospinal fluid of patients with Behçet's disease (2006) Scand J Rheumatol., 64, pp. 655-660Houman, H., Hamzaoui, A., Ghorbel, I., Abnormal expression of chemokine receptors in Behçet's disease: relationship to intracellular Th1/Th2 cytokines and to clinical manifestations (2004) J Autoimmun., 23, pp. 267-273Bank, I., Duvdevani, M., Livneh, A., Expansion of gd T-cells in Behcet's disease: role of disease activity and microbial flora in oral ulcers (2003) J Lab Clin Med., 141, pp. 33-40Verity, D.H., Wallace, G.R., Vaughan, R.W., Stanford, M.R., Behçet's disease-from Hippocrates to the third millennium (2003) Br J Ophthalmol., 87, pp. 1175-1183Zierhut, M., Mizuki, N., Ohno, S., Inoko, L.H.G.A., Onoe, K., Immunology and functional genomics of Behçet's disease (2003) Cell Mol Life Sci., 60, pp. 1903-1922Alpsoy, E., Zouboulis, C.C., Ehrlich, C.E., Mucocutaneous lesions of Behçet's disease (2007) Yonsei Med. J, 48, pp. 573-585Alpsoy, E., Aktekin, M., Er, H., Durusoy, C., Yilmaz, E., A randomizedcontrolled and blinded study of papulopustular lesions in Turkish Behcet's patients (1998) Int J Dermatol., 37, pp. 839-843Alpsoy, E., Donmez, L., Bacanli, A., Apaydin, C., Butun, B., Review of the clinical manifestations' chronology in 60 patients with Behçet's disease (2003) Dermatology., 117, pp. 354-356Verity, D.H., Wallace, G.R., Seed, P.T., Soluble adhesion molecules in Behcet's disease (1998) Ocul Immunol InXamm., 6, pp. 81-92Nobuyoshi, K., Miyazaki, A., Iwata, D., Ohno, S., Stansford, M.R., Chams, H., Ocular features of Behçet's disease: an international collaborative study (2007) Br J Ophthalmol., 91, pp. 1579-1582Kump, L.I., Moeller, K.L., Reed, G.F., Behçet's disease: comparing 3 decades of treatment response at the National Eye Institute (2008) Can J Ophthalmol., 43, pp. 468-472Ando, K., Fujino, Y., Hijikata, K., Izawa, Y., Masuda, K., Epidemiological features and visual prognosis of Behçet's disease (1999) Jpn J Ophthalmol., 43, pp. 312-317Yoshida, A., Kawashima, H., Motoyama, Y., Shibui, H., Kaburaki, T., Shimizu, K., Comparison of patients with Behçet's disease in the 1980s and 1990s (2004) Ophthalmology., 111, pp. 810-815Marshall, S., Behçet's disease (2004) Best Pract Res Clin Rheumatol., 18, pp. 291-311Kump, L.I., Moeller, K.L., Reed, G.F., Kurup, S.K., Nussenblatt, R.B., Levy-Clarke, G.A., Behçet'sdisease: comparing 3 decades of treatment response at the National Eye Institute (2008) Can J Ophthalmol., 43, pp. 468-472Criteria for diagnosis of Behçet'sdisease (1990) Lancet., 335, pp. 1078-1080. , International Study Group for Behçet'sDiseaseElgin, U., Berker, N., Batman, A., Incidence of secondary glaucoma in Behçet disease (2004) J Glaucoma., 13, pp. 441-444Badi, M.A.A., Zyani, M., Kaddouri, S., Niamane, R., Hda, A., Algayres, J.P., Les manifestations articulaires de la maladie de Behçet. Apropos de 79 cas (2007) Rev Med Interne., 29, pp. 277-282Atzeni, F., Sarzi-Puttini, P., Doria, A., Boiardi, L., Papitone, N., Salvarani, C., Behçet'sdisease and cardiovascular involvement (2005) Lupus., 14, pp. 723-726Kural-Seyahi, E., Fresko, I., Seyahi, N., The long-term mortality and morbidity of Behcet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center (2003) Medicine Baltimore., 82, pp. 60-76Ghorbel, I.B., Ennaifer, R., Lamloum, M., Budd-Chiari syndrome associated with Behçet'sdisease (2008) Gastroenterol Clin Biol., 32, pp. 316-320Hamuryudan, V., Er, T., Seyahi, E., Akman, C., Tüzün, H., Fresko, I., Pulmonary artery aneurisms in Behçet'ssyndrome (2004) Am J Med., 117, pp. 867-870Seyahi, E., Hamuryudan, V., Hatemi, G., Infliximab in the treatment of hepatic vein thrombosis (Budd-Chiari syndrome) in 3 patients with Behçet'ssyndrome (2007) Rheumatology., 46, pp. 1213-1214Gurgun, C., Ercan, E., Ceyhan, C., Yavuzgil, O., Zoghi, M., Aksu, K., Cardiovascular involvement in Behcet's disease (2002) Jpn Heart J., 43, pp. 389-398Morelli, S., Perrone, C., Ferrante, L., Cardiac involvement in Behçet's disease (1997) Cardiology., 88, pp. 513-517Ozkan, M., Emel, O., Özdemir, M., M-Mode2-D and Doppler echocardiography study in 65 patients with Behçet's syndrome (1992) Eur Heart J., 13, pp. 638-641Yurdakul, S., Tuzuner, N., Yurdakul, I., Hamuryudan, V., Yazici, H., Gastrointestinal involvement in Behcet's syndrome: a controlled study (1996) Ann Rheum Dis., 55, p. 20810Hassard, P.V., Binder, S.W., Nelson, V., Vasiliauskas, E.A., Anti-tumor necrosis factor monoclonal antibody therapy for gastrointestinal Behçet's disease: a case report (2001) Gastroenterology., 120, pp. 995-999Akman-Demir, G., Serdaroglu, P., Tasçi, B., Neuro-Behçet Study Group. Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients (1999) Brain, 122, pp. 2171-2181Benamour, S., Naji, T., Alaoui, F.Z., El-Kabli, H., El-Aidouni, S., Neurological involvement in Behcet's disease. 154 cases from a cohort of 925 patients and review of the literature (2006) Rev Neurol., 162, pp. 1084-1090Al-Araji, A., Kidd, D.P., Neuro-Behçet's disease: epidemiologyclinical characteristicsand management (2009) Lancet Neurol., 8, pp. 192-204Hentati, F., Fredj, M., Gharbi, N., Hamida, M., Clinical and biological aspects of neuro-Behçet's in Tunisia (1993) Elsevier., pp. 415-418. , In: Wechsler BGodeau Peds. Behçet's disease. AmsterdamLo Monaco, A., La Corte, R., Caniatti, L., Borrelli, M., Trotta, F., Neurological involvement in North Italian patients with Behset disease (2006) Rheumatol Int., 26, pp. 1113-1119Barros, R., Santos, E., Moreira, B., Clinical characterization and pattern of neurological involvement of Behçet's disease in fifteen Portuguese patients (2007) Clin Exp Rheumatol., 24 (SUPPL. 42), pp. S31Joseph, F.G., Scolding, N.J., Neuro-Behçet's disease in caucasians: a study of 22 patients (2007) Eur J Neurol., 14, pp. 174-180Lee, S.H., Yoon, P.H., Park, S.J., Kim, D.I., MRI findings in neuro-Behçet's disease (2001) Clin Radiol., 56, pp. 485-494Kural-Seyahi, E., Fresko, I., Seyahi, N., The long-term mortality and morbidity of Behset syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center (2003) Medicine Baltimore., 82, pp. 60-76Hirohata, S., Histopathology of central nervous system lesions in Behçet's disease (2008) J Neurol Sci., 267, pp. 41-47Hadfield, M.G., Aydin, F., Lippman, H.R., Kubal, W.S., Sanders, K.M., Neuro-Behçet's disease (1996) Clin Neuropathol., 15, pp. 249-255Arai, Y., Kohno, S., Takahashi, Y., Miyajima, Y., Tsutusi, Y., Autopsy case of neuro-Behçet's disease with multifocal neutrophilic perivascular inflammation (2006) Neuropathology., 26, pp. 579-585Scardamaglia, L., Desmond, P.M., Gonzales, M.F., Bendrups, A., Brotdmann, A., Kay, T.W.H., Behçet's disease with cerebral vasculitis (2001) Int Med J., 31, pp. 560-561Lee, S.H., Yoon, P.H., Park, S.J., Kim, D.I., MRI fi ndings in neuro-Behçet's disease (2001) Clin Radiol., 56, pp. 485-494Koçer, N., Islak, C., Siva, A., CNS involvement in neuro-Behset syndrome: an MR study (1999) Am JNeuroradiol., 20, pp. 1015-1024Siva, A., Kantarci, O.H., Saip, S., Behçet's disease: diagnostic and prognostic aspects of neurological involvement (2001) J Neurol., 248, pp. 95-103Yazici, H., Fresko, I., Yurdakul, S., Behçet's syndrome: disease manifestationsmanagementand advances in treatment (2007) Nat Clin Pract Rheumatol., 3, pp. 148-155Leiba, M., Seligson, U., Sidi, Y., Thrombophilic factors are not the leading cause of thrombosis in Behçet's disease (2004) Ann Rheum Dis., 63, pp. 1445-1449Kidd, D., Steuer, A., Denman, A.M., Rudge, P., Neurological complications of Behçet's syndrome (1999) Brain., 122, pp. 2183-2194Al-Fahad, S., Al-Araji, A., Neuro-Behçet's disease in Iraq: a study of 40 patients (1999) J Neurol Sci., 170, pp. 105-111Houman, M.H., Neff Ati, H., Braham, A., Behçet's disease in Tunisia. Demographicclinical and genetic aspects in 260 patients (2007) Clin Exp Rheumatol., 25 (SUPPL. 45), pp. S58-64Kermode, A.G., Plant, G.T., MacManus, D.G., Kendall, B.E., Kingsley, D.P.E., Moseley, I.F., Behçet's disease with slowly enlarging midbrain mass on MRI: resolution following steroid therapy (1989) Neurology., 39, pp. 1251-1252Mason, R.M., Barnes, C.G., Behçet's syndrome with arthritis (1969) Ann Rheum Dis., 28, pp. 73-78Mizushima, Y., Recent research into Behçet's disease in Japan (1988) Int J Tissue React., 10, pp. 59-65O'Duffy, J.D., Crite' res proposes pour la diagnostic maladie Beh$et et notes the' rapeutiques (1974) Rev Med Interne., 36, pp. 2371-2379Rigby, A.S., Chamberlain, M.A., Bhakta, B., Behçet'sdisease (1995) Baillieres Clin Rheumatol., 9, pp. 375-395Criteria for diagnosis of Behçet'sdisease (1990) Lancet., 335, pp. 1078-1080. , International Study Group for Behçet'sdiseaseEvaluation of diagnostic (classification) criteria in Behçet'sdisease-towards internationally agreed criteria (1992) Br J Rheumatol., 31, pp. 299-308. , International Study Group for Behçet'sdiseaseRussell, A.I., Lawson, W.A., Haskard, D.O., Potential new therapeutic options in Behcet's syndrome (2001) BioDrugs., 15, pp. 25-35Alpsoy, E., Behçet'sdisease: treatment of mucocutaneous lesions (2005) Clin Exp Rheumatol., 23, pp. 532-539Alpsoy, E., Akman, A., Behçet's disease: an algorithmic approach to its treatment (2009) Arch Dermatol Res., 301, pp. 693-702Conklin, R.J., Blasberg, B., Common inflammatory diseases of the mouth (1991) Int J Dermatol., 30, pp. 323-335Saxen, M.A., Ambrosius, W.T., Rehemtula Al, K.F., Russell, A.L., Eckert, G.J., Sustained relief of oral aphthous ulcer pain from topical diclofenac in hyaluronan: a randomizeddouble-blind clinical trial (1997) Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 84, pp. 356-361Yurdakul, S., Mat, C., Tuzun, Y., Ozyazgan, Y., Hamuryudan, V., Uysal, O., A double-blind trial of colchicine in Behcet's syndrome (2001) Arthritis Rheum., 44, pp. 268-692Sharquie, K.E., Najim, R.A., Abu-Raghif, A.R., Dapsone in Behcet's disease: a doubleblindplacebo-controlledcross-over study (2002) J Dermatol., 29, pp. 267-279Hamuryudan, V., Mat, C., Saip, S., Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome. A randomizeddouble-blindplacebo-controlled trial (1998) Ann Intern Med., 128, pp. 443-450Jorizzo, J.L., White, W.L., Wise, C.M., Zanolli, M.D., Sherertz, E.F., Low-dose weekly methotrexate for unusual neutrophilic vascular reactions: cutaneous polyarteritis nodosa and Behçet's disease (1991) J Am Acad Dermatol., 24, pp. 973-978Kikuchi, H., Aramaki, K., Hirohata, S., Low dose MTX for progressive neuro-Behçet's disease. A follow-up study for 4 years (2003) Adv Exp Med Biol., 528, pp. 575-578Suda, H., Low-dose weekly methotrexate therapy for progressive neuro-Behçet's disease (1999) Nihon Rinsho Meneki Gakkai Kaishi., 22, pp. 13-22Davatchi, F., Shahram, F., Chams, H., High dose methotrexate for ocular lesions of Behçet'sdisease. Preliminary shortterm results (2003) Adv Exp Med Biol., 528, pp. 579-584Yazici, H., Pazarli, H., Barnes, C.G., A controlled trial of azathioprine in Behcet's syndrome (1990) N Engl J Med., 322, pp. 281-285Davatchi, F., Shahram, F., Chams, H., Akbarian, M., Pulse cyclophosphamide (PCP) for ocular lesions of Behçet's disease: double blind crossover study (1999) Arthritis Rheum., 42, pp. S320Kötter, I., Günaydin, I., Batra, M., CNS involvement occurs more frequently in patients with Behçet's disease under cyclosporin A (CSA) than under other medications-results of a retrospective analysis of 117 cases (2006) Clin Rheumatol., 25, pp. 482-486Adler, Y.D., Mansmann, U., Zouboulis, C.C., Mycophenolate mofetil is ineVective in the treatment of mucocutaneous Adamantiades-Behçet's disease (2001) Dermatology., 203, pp. 322-324Pipitone, N., Olivieri, I., Cantini, F., Triolo, G., Salvarani, C., New approaches in the treatment of Adamantiades-Behcet's disease (2006) Curr Opin Rheumatol., 18, pp. 3-9Langford, C.A., Drug insight: anti-tumor necrosis factor therapies for the vasculitic diseases (2008) Nat Clin Pract Rheumatol., 4, pp. 364-370Tugal-Tutkun, I., Mudun, A., Urgancioglu, M., Kamali, S., Kasapoglu, E., Inanc, M., Efficacy of infliximab in the treatment of uveitis that is resistant to treatment with the combination of azathioprinecyclosporineand corticosteroids in Behcet's disease: an open-label trial (2005) Arthritis Rheum., 52, pp. 2478-2484Sfikakis, P.P., Behçet's disease: a new target for anti-tumour necrosis factor treatment (2002) Ann Rheum Dis., 61, pp. 51-53Triolo, G., Vadala, A., Accardo-Palumbo, A., Ferrante, A., Ciccia, F., Giardina, E., Anti-tumour necrosis factor monoclonal antibody treatment for ocular Behçet's disease (2002) Ann Rheum Dis., 61, pp. 560-561Gulli, S., Arrigo, C., Bocchino, L., Morgante, L., Sangari, D., Castagna, I., Remission of Behçet's disease with anti-tumour necrosis factor monoclonal antibody therapy: a case report (2003) BMC Musculoskelet Disord., 4, p. 19Ohno, S., Nakamura, S., Hori, S., Shimakawa, M., Kawashima, H., Mochizuki, M., Efficacysafetyand pharmacokinetics of multiple administration of infliximab in Behcet's disease with refractory uveoretinitis (2004) J Rheumatol., 31, pp. 1362-1368Mushtaq, B., Saeed, T., Situnayake, R.D., Murray, P.I., Adalimumab for sightthreatening uveitis in Behcet's disease (2007) Eye., 21, pp. 824-825Furst, D.E., Keystone, E.C., Kirkham, B., Kavanaugh, A., Fleischmann, R., Mease, P., Updated consensus statement on biological agents for the treatment of rheumatic diseases (2008) Ann Rheum Dis., 67, pp. 11122-5Hatemi, G., Silman, A., Bang, D., EULAR recommendations for the management of Behset disease (2008) Ann Rheum Dis., 67, pp. 1656-1662