Artículos de revistas
Ferruginol Suppresses Survival Signaling Pathways In Androgen-independent Human Prostate Cancer Cells
Registro en:
Biochimie. , v. 90, n. 6, p. 843 - 854, 2008.
3009084
10.1016/j.biochi.2008.01.011
2-s2.0-44449164361
Autor
Bispo de Jesus M.
Zambuzzi W.F.
Ruela de Sousa R.R.
Areche C.
Santos de Souza A.C.
Aoyama H.
Schmeda-Hirschmann G.
Rodriguez J.A.
Monteiro de Souza Brito A.R.
Peppelenbosch M.P.
den Hertog J.
de Paula E.
Ferreira C.V.
Institución
Resumen
Ferruginol, a bioactive compound isolated from a Chilean tree (Podocarpaceae), attracts attention as a consequence of its pharmacological properties, which include anti-fungal, anti-bacterial, cardioprotective, anti-oxidative, anti-plasmodial and anti-ulcerogenic actions. Nevertheless, the molecular basis for these actions remains only partly understood and hence we investigated the effects of ferruginol on androgen-independent human prostate cancer cells (PC3), a known model for solid tumor cells with an exceptional resistance to therapy. The results show that ferruginol induces PC3 cell death via activation of caspases as well as apoptosis-inducing factor (AIF) as confirmed by its translocation into the nucleus. In order to clarify the biochemical mechanism responsible for the anti-tumor activity of ferruginol, we analyzed a set of molecular mediators involved in tumor cell survival, progression and aggressiveness. 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