Adipose tissue performs many functions in the body, being considered an endocrine organ due to substances secreted, called adipokines. The excess of adipose tissue is called obesity, and it is associated with a state of chronic subclinical inflammation. Various strategies and products have been evaluated in an attempt to prevent and treat obesity, standing out the importance of polyphenols from citrus fruits. This paper aims to review studies developed to evaluate the role of these compounds in obesity and some general trends can be highlighted. The invitro studies indicate that citrus polyphenols could assist in the management of obesity, since they cause a reduction in adipocyte differentiation, lipid content in the cell and adipocyte apoptosis. The biological assays are not entirely consistent; however, most of them indicated a reduction in adipose tissue; increased genes expression indicating a stimulus to β-oxidation; improved lipid profile and glycemia; as well as some evidence of improvement in inflammatory status. Several clinical trials have demonstrated the positive effect of citrus flavonoids in the reduction of proinflammatory cytokines in humans, being beneficial to alleviate the complications present in obesity. However, there are few clinical trials developed to examine its role in reducing adiposity. © 2014 Elsevier Ltd.592P212051212Aherne, S.A., O'Brien, N.M., Dietary flavonols: chemistry, food content, and metabolism (2002) Nutrition, 18 (1), pp. 75-81Alam, M.A., Kauter, K., Brown, L., Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats (2013) Nutrients, 5 (3), pp. 637-650Ameer, B., Weintraub, R.A., Johnson, J.V., Yost, R.A., Rouseff, R.L., Flavanone absorption after naringin, hesperidin, and citrus administration (1996) Clinical Pharmacology and Therapeutics, 60 (1), pp. 34-40Balistreri, C.R., Caruso, C., Candore, G., The role of adipose tissue and adipokines in obesity-related inflammatory diseases (2010) Mediators of Inflammation, 2010, pp. 1-19Benavente-García, O., Castillo, J., Marin, F.R., Ortuño, A., Del Río, J.A., Uses and properties of citrus flavonoids (1997) Journal of Agricultural and Food Chemistry, 45 (12), pp. 4505-4515Bernabé, J., Mulero, J., Cerdá, B., García-Viguera, C., Moreno, D.A., Parra, S., Effects of a citrus based juice on biomarkers of oxidative stress in metabolic syndrome patients (2013) Journal of Functional Foods, 5 (3), pp. 1031-1038Bezerra, R.M.N., Ueno, M., Silva, M.S., Tavares, D.Q., Carvalho, C.R.O., Saad, M.J.A., Ahigh fructose diet affects the early steps of insulin action in muscle and liver of rats (2000) The Journal of Nutrition, 130, pp. 1531-1535Birt, D.F., Hendrich, S., Wang, W., Dietary agents in cancer prevention: flavonoids and isoflavonoids (2001) Pharmacology and Therapeutics, 90 (2-3), pp. 157-177Buscemi, S., Rosafio, G., Arcoleo, G., Mattina, A., Canino, B., Montana, M., Effects of red orange juice intake on endothelial function and inflammatory markers in adult subjects with increased cardiovascular risk (2012) American Journal of Clinical Nutrition, 95, pp. 1089-1095Cho, K.W., Kim, Y.O., Andrade, J.E., Burgess, J.R., Kim, Y.-C., Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats (2011) European Journal of Nutrition, 50 (2), pp. 81-88Dallas, C., Gerbi, A., Elbez, Y., Caillard, P., Zamaria, N., Cloarec, M., Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals (2013) Phytotherapy Research, pp. 1-7Dallas, C., Gerbi, A., Tenca, G., Juchaux, F., Bernard, F.-X., Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE) (2008) Phytomedicine, 15, pp. 783-792Devaraj, S., Jialal, I., Rockwood, J., Zak, D., Effect of orange juice and beverage with phytosterols on cytokines and PAI-1 activity (2011) Clinical Nutrition, 30 (5), pp. 668-671Ding, X., Fan, S., Lu, Y., Zhang, Y., Gu, M., Zhang, L., Citrus ichangensis peel extract exhibits anti-metabolic disorder effects by the inhibition of PPARγ and LXR signaling in high-fat diet-induced C57BL/6 mouse (2012) Evidence-Based Complementary and Alternative Medicine, 2012, pp. 1-10Escarpa, A., Gonzalez, M.C., An overview of analytical chemistry of phenolic compounds in foods (2001) Critical Reviews in Analytical Chemistry, 31 (2), pp. 57-139Fukuchi, Y., Hiramitsu, M., Okada, M., Hayashi, S., Nabeno, Y., Lemon polyphenols suppress diet-induced obesity by up-regulating of mRNA levels of the enzymes involved in beta-oxidation in mouse white adipose tissue (2008) Journal of Clinical Biochemistry and Nutrition, 43, pp. 201-209. , NovemberGattuso, G., Barreca, D., Garguilli, C., Leuzzi, U., Caristi, C., Flavonoid composition of citrus juices (2007) Molecules, 12, pp. 1641-1673Ghasemi, K., Ghasemi, Y., Ebrahimzadeh, M.A., Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues (2009) Pakistan Journal of Pharmaceutical Sciences, 22 (3), pp. 277-281González-Barrio, R., Trindade, L.M., Manzanares, P., de Graaff, L.H., Tomás-Barberán, F.A., Espín, J.C., Production of bioavailable flavonoid glucosides in fruit juices and green tea by use of fungal alpha-L-rhamnosidases (2004) Journal of Agricultural and Food Chemistry, 52 (20), pp. 6136-6142Grundy, S.M., Brewer, H.B., Cleeman, J.I., Smith, S.C., Lenfant, C., Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition (2004) Circulation, 109, pp. 433-438Hotamisligil, G.S., Shargill, N.S., Spiegelman, B.M., Adipose expression of tumor necrosis factor-alfa: direct role in obesity-linked insulin resistance (1993) Science, 259, pp. 87-91. , JanuaryIwamoto, M., Imai, K., Ohta, H., Shirouchi, B., Sato, M., Supplementation of highly concentrated β-cryptoxanthin in a satsuma mandarin beverage improves adipocytokine profiles in obese Japanese women (2012) Lipids in Health and Disease, 11 (52), pp. 1-4Jung, H.K., Jeong, Y.S., Park, C.-D., Park, C.-H., Hong, J.-H., Inhibitory effect of citrus peel extract on lipid accumulation of 3T3-L1 adipocytes (2011) Journal of the Korean Society for Applied Biological Chemistry, 54 (2), pp. 169-176Kanda, K., Nishi, K., Kadota, A., Nishimoto, S., Liu, M.-C., Sugahara, T., Nobiletin suppresses adipocyte differentiation of 3T3-L1 cells by an insulin and IBMX mixture induction (2012) Biochimica et Biophysica Acta, 1820, pp. 461-468Kang, S.-I., Shin, H.-S., Kim, H.-M., Hong, Y.-S., Yoon, S.-A., Kang, S.-W., Immature Citrus sunki peel extract exhibits antiobesity effects by β-oxidation and lipolysis in high-fat diet-induced obese mice (2012) Biological & Pharmaceutical Bulletin, 35 (2), pp. 223-230Kelley, G.L., Allan, G., Azhar, S., High dietary fructose induces a hepatic stress response resulting in cholesterol and lipid dysregulation (2004) Endocrinology, 145 (2), pp. 548-555Kershaw, E.E., Flier, J.S., Adipose tissue as an endocrine organ (2004) The Journal of Clinical Endocrinology & Metabolism, 89 (6), pp. 2548-2556Kim, H.Y., Park, M., Kim, K., Lee, Y.M., Rhyu, M.R., Hesperetin stimulates cholecystokinin secretion in enteroendocrine STC-1 cells (2013) Biomolecules & Therapeutics, 21 (2), pp. 121-125Kim, G.-S., Park, H.J., Woo, J.-H., Kim, M.-K., Koh, P.-O., Min, W., Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells (2012) BMC Complementary and Alternative Medicine, 12 (31), pp. 1-10Klimczak, I., Małecka, M., Szlachta, M., Gliszczyńska-Świgło, A., Effect of storage on the content of polyphenols, vitamin C and the antioxidant activity of orange juices (2007) Journal of Food Composition and Analysis, 20 (3-4), pp. 313-322Lee, Y.-S., Cha, B.-Y., Choi, S.-S., Choi, B.-K., Yonezawa, T., Teruya, T., Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice (2013) The Journal of Nutritional Biochemistry, 24, pp. 156-162Lee, Y.-S., Cha, B.-Y., Saito, K., Choi, S.-S., Wang, X.X., Choi, B.-K., Effects of a Citrus depressa Hayata (shiikuwasa) extract on obesity in high-fat diet-induced obese mice (2011) Phytomedicine, 18, pp. 648-654Le Lay, S., Dugail, I., Connecting lipid droplet biology and the metabolic syndrome (2009) Progress in Lipid Research, 48, pp. 191-195Li, R.W., Theriault, A.G., Au, K., Douglas, T.D., Casaschi, A., Kurowska, E.M., Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters (2006) Life Sciences, 79, pp. 365-373Londoño-Londoño, J., Lima, V.R.D., Lara, O., Gil, A., Pasa, T.B.C., Arango, G.J., Clean recovery of antioxidant flavonoids from citrus peel: optimizing an aqueous ultrasound-assisted extraction method (2010) Food Chemistry, 119 (1), pp. 81-87Macheix, J.-J., Fleuriet, A., Billot, J., (1990) Fruit phenolics, , CRC Press, FloridaMadeira, J.V., Macedo, J.A., Macedo, G.A., Anew process for simultaneous production of tannase and phytase by Paecilomyces variotii in solid-state fermentation of orange pomace (2012) Bioprocess Biosystems Engineering, 8551, pp. 1-7Manthey, J.A., Grohmann, K., Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses (2001) Journal of Agricultural and Food Chemistry, 49, pp. 3268-3273Miller, N.J., Rice-Evans, C.A., The relative contributions of ascorbic acid and phenolic antioxidants to the total antioxidant activity of orange and apple fruit juices and blackcurrant drink (1997) Food Chemistry, 60 (3), pp. 331-337Miyake, Y., Sakurai, C., Usuda, M., Fukumoto, S., Hiramitsu, M., Sakaida, K., Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans (2006) Journal of Nutritional Science and Vitaminology, 52, pp. 54-60Morand, C., Dubray, C., Milenkovic, D., Lioger, D., Martin, J.F., Scalbert, A., Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers (2011) American Journal of Clinical Nutrition, 93, pp. 73-80Nielsen, I.L.F., Chee, W.S.S., Poulsen, L., Offord-Cavin, E., Rasmussen, S.E., Frederiksen, H., Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial (2006) The Journal of Nutrition, 136, pp. 404-408Persson, J., Degerman, E., Nilsson, J., Lindholm, M.W., Perilipin and adipophilin expression in lipid loaded macrophages (2007) Biochemical and Biophysical Research Communications, 363, pp. 1020-1026Raasmaja, A., Lecklin, A., Li, X.M., Zou, J., Zhu, G.-G., Laakso, I., Awater-alcohol extract of Citrus grandis whole fruits has beneficial metabolic effects in the obese Zucker rats fed with high fat/high cholesterol diet (2013) Food Chemistry, 138, pp. 1392-1399Ramalho, R., Guimarães, C., Papel do tecido adiposo e dos macrófagos no estado de inflamação crónica associada à obesidade - implicações clínicas (2008) Acta Medica Portuguesa, 21, pp. 489-496Ramful, D., Bahorun, T., Bourdon, E., Tarnus, E., Aruoma, O.I., Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application (2010) Toxicology, 278 (1), pp. 75-87Raybould, H.E., Mechanisms of CCK signaling from gut to brain (2009) Current Opinion in Pharmacology, 7 (6), pp. 570-574Sabroe, I., Parker, L., Dower, S., Whyte, M., The role of TLR activation in inflammation (2008) The Journal of Pathology, pp. 126-135Salamone, F., Li Volti, G., Titta, L., Puzzo, L., Barbagallo, I., La Delia, F., Moro orange juice prevents fatty liver in mice (2012) World Journal of Gastroenterology, 18 (29), pp. 3862-3868Sergeev, I.N., Li, S., Ho, C.-T., Rawson, N.E., Dushenkov, S., Polymethoxyflavones activate Ca2+-dependent apoptotic targets in adipocytes (2009) Journal of Agricultural and Food Chemistry, 57, pp. 5771-5776Stuetz, W., Prapamontol, T., Hongsibsong, S., Biesalski, H.-K., Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines (Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand (2010) Journal of Agricultural and Food Chemistry, 58 (10), pp. 6069-6074Sun, Y., Qiao, L., Shen, Y., Jiang, P., Chen, J., Ye, X., Phytochemical profile and antioxidant activity of physiological drop of citrus fruits (2013) Journal of Food Science, 78 (1), pp. C37-C42Tripoli, E., Guardia, M.L., Giammanco, S., Majo, D.D., Giammanco, M., Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review (2007) Food Chemistry, 104, pp. 466-479Turner, T., Burri, B.J., Potential nutritional benefits of current citrus consumption (2013) Agriculture, 3, pp. 170-187Um, M.Y., Moon, M.K., Ahn, J., Youl Ha, T., Coumarin attenuates hepatic steatosis by down-regulating lipogenic gene expression in mice fed a high-fat diet (2013) The British Journal of Nutrition, 109, pp. 1590-1597Wang, M.-J., Chao, P.L., Hou, Y.-C., Hsiu, S.-L., Wen, K.-C., Tsai, S.-Y., Pharmacokinetics and conjugation metabolism of naringin and naringenin in rats after single dose and multiple dose administrations (2006) Journal of Food and Drug Analysis, 14 (3), pp. 247-253Weisberg, S.P., Mccann, D., Desai, M., Rosenbaum, M., Leibel, R.L., Ferrante, A.W., Obesity is associated with macrophage accumulation in adipose tissue (2003) The Journal of Clinical Investigation, 112 (12), pp. 1796-1808Yoshida, H., Takamura, N., Shuto, T., Ogata, K., Tokunaga, J., Kawai, K., The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes (2010) Biochemical and Biophysical Research Communications, 394, pp. 728-732Yoshida, H., Watanabe, W., Oomagari, H., Tsuruta, E., Shida, M., Kurokawa, M., Citrus flavonoid naringenin inhibits TLR2 expression in adipocytes (2013) The Journal of Nutritional Biochemistry, 24 (7), pp. 1276-1284