Actas de congresos
In Vitro Determination Of The Sun Protection Factor Of Sunscreens Through Photoacoustic Spectroscopy: A New Approach
Registro en:
European Physical Journal: Special Topics. , v. 153, n. 1, p. 475 - 478, 2008.
19516355
10.1140/epjst/e2008-00488-2
2-s2.0-40949106932
Autor
Oliveira S.L.
Mansanares A.M.
da Silva E.C.
Barja P.R.
Institución
Resumen
The investigation of the sun protection factor (SPF) and the efficacy of ultraviolet absorber ingredients are extremely important items for the cosmetic industry. The development of new efficient in vitro methodologies for these investigations is an essential condition for the evolution of sunscreens. The most accepted test for assessing the efficacy of sunscreens is the in vivo (in humans) SPF determination, following validated and worldwide adopted methodologies like those regulated by FDA (USA), COLIPA (Europe) and JCIA (Japan). However, due to the high costs and time consumption of in vivo SPF determination, the constant development of in vitro methods able to predict the in vivo SPF is very important. The present study evaluates different experimental methods for in vitro SPF determination - photoacoustic spectroscopy (PAS) and transmission spectroscopy (TS), employing different substrates (PMMA and VitroSkin®) and concentrations (0.8 mg/cm2 and 2 mg/cm2). Results are compared to the labeled SPF. The high correlation between the labeled SPF and the SPF determined by PAS expands the application of this technique in the photobiology field. © EDP Sciences/Societé Italiana di Fisica/Springer-Verlag 2008. 153 1 475 478 Stokes, R., Diffey, B.L., (1999) Int. J. Cosmet. Sci., 21, p. 341 Cole, C., (2001) Photodermatol Photoimmunol Photomed., 17, p. 2 (1998), AS/NZS - Australian/New Zealand Standard 2604(2004), DIN - German Standard DIN 67502 (January)Anjos, F.H., (2004) Opt. Diag. Sens. IV, pp. 143-149. , (SPIE, Bellingham) (2006) SPF Analysis of Sunscreens - Technical Note, , http://www.labsphere.com, Labsphere Inc. available at McKinlay, A.F., Diffey, B.L., A reference action spectrum for ultra-violet induced erythema in human skin (1987) Human Exposure to Ultraviolet Radiation: Risks and Regulations, pp. 83-87. , in edited by W.F. Passchier, B.F.M. Bosnjakovich (Int. Congress Series) Diffey, B.L., (1998) Sunscreens - Development, Evaluation and Regulatory Aspects, , 2nd edn