Artículos de revistas
Effects Of Nitric Oxide On The Retinal Spreading Depression
Registro en:
Brain Research. , v. 691, n. 1-2, p. 239 - 242, 1995.
68993
10.1016/0006-8993(95)00737-B
2-s2.0-0029096928
Autor
Ulmer H.J.
Fernandes de Lima V.M.
Hanke W.
Institución
Resumen
The retinal spreading depression has been used as a tool to investigate the action of nitric oxide (NO) as a diffusible neurotransmitter which in many cases acts by raising the cGMP level in target cells. The role of NO as a vasodilating agens has been well-established and it has been suggested that the vasodilatation concurrent with cortical SD may be mediated by NO. In this study, we present pure neuronal effects of NO on SD as the chicken retina is void of bloodvessels. We show that NO directly decreases the velocity of retinal SD waves in a concentration-and time-dependent manner. This effect can be partially mimicked by application of membrane-permeable cGMP derivatives. Furthermore, a NO-mediated speed up of the recovery of the intrinsic optical signal after the wave-front is shown. © 1995. 691 1-2 239 242 Ahmad, Leinders-Zufall, Kocsis, Shepherd, Zufall, Barnstable, Retinal ganglion cells express a cGMP-gated cation conductance activable by nitric oxide donors (1994) Neuron, 12, pp. 155-165 Edelmann, Gally, Nitric oxide linking space and time in the brain (1992) Proceedings of the National Academy of Sciences, 89, pp. 11651-11652 Garthwaite, Nitric oxide signalling in the nervous system (1993) Sem. Neurosci., 5, pp. 171-180 Gault, Lin, LaManna, Lust, Changes in energy metabolites, cGMP and intracellular pH during cortical spreading depression (1994) Brain Res., 641, pp. 176-180 Gotzes, Müller, de Vente, Nitric oxide stimulates cGMP-synthesis in neurons of the vertebrate retina (1995) Proceedings of the 23rd Göttingen Neurobiology Conference, p. 452. , N. Elsner, R. Menzels Gouras, Spreading depression of activity in amphibian retina (1958) Am. J. Physiol., 195, pp. 28-32 Gouras, Spreading depression of activity in amphibian retina (1958) Annu. Rev. Physiol., 54, pp. 153-175 Kow, Van Harreveld, Ion and water movements in isolated chicken retinas during spreading depression (1972) Neurobiology, 2, pp. 61-69 Lashley, Patterns of cerebral integration indicated by the scotomas of migraine (1941) Archives of Neurology And Psychiatry, 45, pp. 331-339 Leão, Spreading depression of activity in the cerebral cortex (1944) J. Neurophysiol., 7, pp. 359-390 Loiacono, Beart, Hippocampal lesions induced by microinjection of the nitric oxide donor nitroprusside (1992) Eur. J. Pharmacol., 216, pp. 331-333 Martins-Ferreira, de Oliveira Castro, Light scattering changes accompanying spreading depression in isolated retina (1966) J. Neurophysiol., 29, pp. 715-726 Mayer, Molecular characteristics and enzymology of nitric oxide synthase and soluble guanylyl cyclase in the CNS (1993) Sem. Neurosci., 5, pp. 197-205 Milner, A note on the possible correspondence between the scotomas of migraine and spreading depression of Leão (1958) Electroencephalogr. Clin. Neurophysiol., 10, p. 705 Olesen, Iverson, Thomson, Nitric oxid supersensitivity: a possible molecular mechanism of migraine pain (1993) NeuroReport, 4, pp. 1027-1030 Wahl, Schilling, Parsons, Kaumann, Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilatation elicited by cortical spreading depression (1994) Brain Res., 637, pp. 204-210