Artículos de revistas
Incidence Of Aplastic Anemia And Agranulocytosis In Latin America - The Latin Study
Registro en:
Sao Paulo Medical Journal. , v. 123, n. 3, p. 101 - 104, 2005.
15163180
2-s2.0-22244476102
Autor
Hamerschlak N.
Maluf E.
Pasquini R.
Eluf-Neto J.
Moreira F.R.
Biasi Cavalcanti A.
Ruriko Okano I.
Passeto Falcao R.
Teixeira Pita M.
Loggetto S.R.
Gastao Rosenfeld L.
Lorand-Metze I.G.H.
Institución
Resumen
Context and objective: Aplastic anemia and agranulocytosis are rare but life-threatening disorders, often caused by drugs and other environmental exposures. Reported incidence of these diseases seems to vary between different geographic regions, and few data on their incidence are available for Latin American countries. The aim of this work is to determine the incidence of agranulocytosis and aplastic anemia in Brazil. Design and setting: Incidence study. Seven centers took part in the pilot phase, so as to represent all Brazilian regions. Methods: Each center conducted an active search for new cases in a defined region by means of regular contacts with all hematologists, main clinical laboratories and clinicians in hospitals of the region. Results: 74 patients with aplastic anemia and 16 with agranulocytosis were identified. Patients with agranulocytosis had a median age of 31 years (interquartile range, IQR: 12.5-48.2); 32.2% were male and 81.2% were white. The median age of aplastic anemia patients was 21 years (IQR 15.0-35.2); 62.2% were male, 50.0% were white and 39.2% mulatto. The incidence of agranulocytosis was estimated to be 0.5 cases per million individuals per year, ranging from 0.0 to 1.1 cases per million per year between regions. The incidence of aplastic anemia was 2.7 cases per million per year, ranging from 1.1 to 7.1 cases per million per year between regions. Conclusions: Aplastic anemia and agranulocytosis are rare diseases in Brazil. However, there is considerable variability in their incidences between different regions. Copyright © 2005, Associação Paulista de Medicina. 123 3 101 104 Hamerschlak, N., Montezuma, M.P., Bacal, N., Szterling, L.N., Rosenfeld, L.G., Guerra, C.C., Retrospective prevalence and incidence of drug-induced agranulocytosis in the city of São Paulo - Brazil (1993) Rev. Paul Med., 111 (1), pp. 294-298 Strom, B.L., Carson, J.L., Schinnar, R., Snyder, E.S., Shaw, M., Descriptive epidemiology of agranulocytosis (1992) Arch. Intern. Med., 152 (7), pp. 1475-1480 Kaufman, D.W., Kelly, J.P., Jurgelon, J.M., Drugs in the aetiology of agranulocytosis and aplastic anaemia (1996) Eur. J. Haematol. Suppl., 60, pp. 23-30 Böttiger, L.E., Furhoff, A.K., Holmberg, L., Drug-induced blood dyscrasias (1979) Acta Med. Scand., 205 (6), pp. 457-461. , A ten-year material from the Swedish Adverse Drug Reaction Committee Wiholm, B.E., Emanuelsson, S., Drug-related blood dyscrasias in a Swedish reporting system, 1985-1994 (1996) Eur. J. Haematol. Suppl., 60, pp. 42-46 van der Klauw, M.M., Goudsmit, R., Halie, M.R., A population-based case-cohort study of drug-associated agranulocytosis (1999) Arch. Intern. Med., 159 (4), pp. 369-374 Maluf, E.M., Pasquini, R., Eluf, J.N., Kelly, J., Kaufman, D.W., Aplastic, anemia in Brazil: Incidence and risk factors (2002) Am. J. Hematol., 71 (4), pp. 268-274 Tichelli, A., Socié, G., Henry-Amar, M., Effectiveness of immunosuppressive therapy in older patients with aplastic anemia (1999) Ann. Intern. Med., 130 (3), pp. 193-201. , European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party Rich, M.L., Ritterhoff, R.J., Hoffmann, R.J., A fatal case of aplastic anemia following chloramphenicol (chloromycetin) therapy (1950) Ann. Intern. Med., 33 (6), pp. 1459-1467 Scott, J.L., Cartwright, G.E., Wintrobe, M.M., Acquired aplastic anemia: An analysis of thirty-nine cases and review of the pertinent literature (1959) Medicine (Baltimore), 38 (2), pp. 119-172 Dorr, V.J., Cook, J., Agranulocytosis and near fatal sepsis due to 'Mexican aspirin' (dipyrone) (1996) South Med. J., 89 (6), pp. 612-614 Kaufman, D.W., Kelly, J.P., Johannes, C.B., Acute thrombocytopenic purpura in relation to the use of drugs (1993) Blood, 82 (9), pp. 2714-2718 (2000), http://www.ibge.gov.br/censo/default.php, Brasil. Ministério do Planejamento, Orçamento e Gestão. Censo Available from URL: Accessed in 2005 (Apr 12)Kaufman, D.W., Kelly, J.P., Levy, M., Shapiro, S., (1999) The Drug Etiology of Agranulocytosis and Aplastic Anemia, , New York: Oxford University Press Issaragrisil, S., Sriratanasatavorn, C., Piankijagum, A., Incidence of aplastic anemia in Bangkok (1991) Blood, 77 (10), pp. 2166-2168. , The Aplastic Anemia Study Group Benítez-Aranda, H., Vélez-Ruelas, M.A., Díaz-Cárdenas, S., Incidence of aplastic anemia in a defined subpopulation from Mexico City (2002) Hematology, 7 (4), pp. 229-232