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Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
(Nature Publishing Group, 2018-12-18)
Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is ...
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
(American Physiological Society, 2014)
Insulin is a major
regulator of glucose metabolism, stimulating its mitochondrial oxidation
in skeletal muscle cells. Mitochondria are dynamic organelles that
can undergo structural remodeling in order to cope with these ...
Mitochondrial chaotic dynamics: Redox-energetic behavior at the edge of stability
(2018-10-18)
Mitochondria serve multiple key cellular functions, including energy generation, redox balance, and regulation of apoptotic cell death, thus making a major impact on healthy and diseased states. Increasingly recognized is ...
Mitochondrial Dynamics In Adaptive And Maladaptive Cellular Stress Responses
(2018)
Mitochondria sense and respond to many stressors and can support cell survival or death through energy production and signalling pathways. Mitochondrial responses depend on fusion-fission dynamics that dilute and segregate ...
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis
(2008)
AIMS: In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
Mitochondrial dynamics: A potential new therapeutic target for heart failure Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca
(2011)
Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease
(Elsevier B.V., 2018)
© 2018 The Authors In the last few decades, many reports have suggested that mitochondrial function impairment is a hallmark of Alzheimer's disease (AD). Although AD is a neurodegenerative disorder, mitochondrial damage ...
Toxicity of blue led light and A2E is associated to mitochondrial dynamics impairment in ARPE-19 cells: implications for age-related macular degeneration
(Springer Verlag Berlín, 2019-02)
Age-related macular degeneration (AMD) is a multifactorial retinal disease characterized by a progressive loss of central vision. Retinal pigment epithelium (RPE) degeneration is a critical event in AMD. It has been ...
Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake
(2014)
Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
(Wiley-VCH Verlag, 2014)