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Vagal stimulation mimics preconditioning and postconditioning of ischemic myocardium in mice by activating different protection mechanisms
(American Physiological Society, 2018-06)
Vagal stimulation (VS) during myocardial ischemia and reperfusion has beneficial effects. However, it is not known whether short-term VS applied before ischemia or at the onset of reperfusion protects the ischemic myocardium. ...
Role of Pairwise Interactions between M1 and M2 Domains of the Nicotinic Receptor in Channel Gating
(Cell Press, 2007-01)
The adult form of the nicotinic acetylcholine receptor (AChR) consists of five subunits (α2βɛδ), each having four transmembrane domains (M1–M4). The atomic model of the nicotinic acetylcholine receptor shows that the ...
Consecuencias funcionales de la evolución adaptativa del receptor nicotínico alfa 9 alfa 10Functional consequences of adaptive evolution of the alfa 9 y alfa 10 nicotinic receptor
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2011)
Constitutive expression of the alpha10 nicotinic acetylcholine receptor subunit fails to maintain cholinergic responses in inner hair cells after the onset of hearing
(Springer, 2009-05)
Efferent inhibition of cochlear hair cells is mediated by α9α10 nicotinic cholinergic receptors (nAChRs) functionally coupled to calcium-activated, small conductance (SK2) potassium channels. Before the onset of hearing, ...
Mechanistic contributions of residues in the M1 transmembrane domain of the nicotinic receptor to channel gating
(Taylor & Francis Ltd, 2004-01)
The nicotinic receptor (AChR) is a pentamer of homologous subunits with an α2βεδ composition in adult muscle. Each subunit contains four transmembrane domains (M1-M4). Position 15′ of the M1 domain is phenylalanine in α ...
Localization of agonist and competitive antagonist binding sites on nicotinic acetylcholine receptors
(Pergamon-Elsevier Science Ltd, 2000-06-01)
Identification of all residues involved in the recognition and binding of cholinergic ligands (e.g. agonists, competitive antagonists, and noncompetitive agonists) is a primary objective to understand which structural ...
Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling
(2020-04-02)
Fear memory extinction (FE) is an important therapeutic goal for Posttraumatic stress disorder (PTSD). Cotinine facilitates FE in rodents, in part due to its inhibitory effect on the amygdala by the glutamatergic projections ...
Nicotine modulates the long-lasting storage of fear memory
(Cold Spring Harbor Lab Press, 2013-02)
Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, ...