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Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer
(Future Medicine Ltd., 2016)
Current strategies for brain diseases are mostly symptomatic and noncurative. Nanotechnology has
the potential to facilitate the transport of drugs across the blood-brain barrier and to enhance their
pharmacokinetic ...
Hormesis: Protecting neurons against cellular stress in Parkinson disease
(Taylor and Francis Inc., 2012)
Protein folding stress is a salient feature of the most frequent neurodegenerative diseases. Although the accumulation of abnormally folded proteins is a well-characterized event underlying the pathology, the way cells ...
An ERcentric view of Parkinson's disease
(2013)
Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...
Targeting autophagy in ALS: A complex mission
(Taylor and Francis Inc., 2011)
Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study
(Springer, 2015)
Neurodegenerative diseases of the central nervous system are characterized by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal ...
ERp57 in neurodegeneration and regeneration
(MEDKNOW PUBLICATIONS & MEDIA, 2016)
Protein Misfolding and Neurodegeneration
(American Medical Association, 2008-02)
Akey molecular pathway implicated in diverse neurodegenerative diseases is the misfolding,
aggregation, and accumulation of proteins in the brain. Compelling evidence
strongly supports the hypothesis that accumulation ...
Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer’s disease
(Wiley, 2018)
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid- peptides or phosphorylated tau proteins. Accumulating ...