Artículo de revista
Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer
Fecha
2016Registro en:
Naomedicine Volumen: 11 Número: 2 (2016)
DOI: 10.2217/nnm.15.189
Autor
Catalán Figueroa, Johanna
Palma Florez, Sujey
Alvarez, Gonzalo
Fritz, Hans F.
ara, Miguel O.
Morales, Javier O.
Institución
Resumen
Current strategies for brain diseases are mostly symptomatic and noncurative. Nanotechnology has
the potential to facilitate the transport of drugs across the blood-brain barrier and to enhance their
pharmacokinetic profile. However, to reach clinical application, an understanding of
nanoneurotoxicity in terms of oxidative stress and inflammation is required. Emerging evidence has
also shown that nanoparticles have the ability to alter autophagy, which can induce inflammation
and oxidative stress, or vice versa. These effects may increase neurodegenerative processes
damage, but on the other hand, they may have benefits for brain cancer therapies. In this review,
we emphasize how nanomaterials may induce neurotoxic effects focusing on neurodegeneration,
and how these effects could be exploited toward brain cancer treatment.