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Rat liver microsomal and nuclear activation of methanol to hydroxymethyl free radicals
(Elsevier Ireland, 2002-03)
Recent studies from other laboratories reported that during methanol intoxication lipid peroxidation and protein oxidation in liver occurred. Further, they detected free radicals-PBN adducts in bile and urine of methanol ...
Oxidation of ethanol to acetaldehyde and free radicals by rat testicular microsomes
(Springer, 2005-01)
A large number of epidemiological studies evidencing that excessive alcohol consumption is associated with impaired testosterone production and testicular atrophy are available in the literature. One hypothesis to explain ...
Liver nuclear and microsomal CYP2E1-mediated metabolism of xenobiotics in rats chronically drinking an alcohol-containing liquid diet
(Sage Publications, 2006-10-01)
In previous studies from our laboratory, the presence in highly purified liver nuclei of metabolic pathways for processing ethanol (EtOH); N-nitrosodimethylamine (NDMA); carbon tetrachloride and chloroform was reported. ...
Enantioselective liver microsomal sulphoxidation of albendazole in cattle: effect of nutritional status
(Taylor & Francis Ltd, 2000-04)
1. The enantioselective liver microsomal sulphoxidation of the benzimidazole anthelmintic, albendazole (ABZ), by cattle liver microsomes has been investigated. The influence of nutritional condition on this biotransformation ...
Nifurtimox biotransformation to reactive metabolites or nitrite in liver subcellular fractions and model systems
(Elsevier Ireland, 2002-11)
Liver microsomal (mic); nuclei (N) and mitochondria (mit) anaerobically nitroreduce Nifurtimox (Nfx) in the presence of NADPH generating system. Simultaneous formation of small amounts of nitrite was observed in microsomes ...
Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep
(Pergamon-Elsevier Science Ltd, 2008-09)
Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic compound used in pigs, poultry and humans. Its potential for parasite control in ruminant species is under investigation. The objective of the work described ...
ELISA method for assess liver - Kidney microsomes antibodies [Método ELISA para anticuerpos antimicrosomales hígado-riñón]
(Federación Bioquímica de la Provincia de Buenos Aires, 2004)
Characterization of xenobiotic metabolizing enzymes in bovine small intestinal mucosa
(Wiley Blackwell Publishing, Inc, 2010-02)
The intestinal mucosa plays a capital role in dictating the bioavailability of a large array of orally ingested drugs and toxicants. The activity and the expression of several xenobiotic metabolizing enzymes were measured ...
Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
(Fundação Oswaldo Cruz, 2008-09)
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats ...
Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation
(Elsevier Ireland, 2009-12)
In order to elucidate the effect on mammal systems of new derivatives from 2-hydroxy-3-allyl-naphthoquinone, á-iodinated naphthofuranquinone (NPPN-3223), â-iodinated naphthofuranquinone (NPPN-3222) and â-methyl naphthofuranquinone ...