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Junin virus triggers macrophage activation and modulates polarization according to viral strain pathogenicity
(Frontiers Media S.A., 2019-10)
The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the ...
M1 macrophage polarization prevails in EBV infected children in an immuneregulatory environment
(American Society for Microbiology, 2021-10-29)
Macrophages can be polarized toward a proinflammatory phenotype (M1) (CD68+) or to an anti-inflammatory one (M2) (CD163+). Polarization can be triggered by cytokines such as IFN-γ for M1, or IL-10 and TGF-β, for M2. In the ...
Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice
(Elsevier Science, 2014-12)
Trypanosoma cruzi, the etiological agent of Chagas' disease, induces a persistent inflammatory response. Macrophages are a first line cell phenotype involved in the clearance of infection. Upon parasite uptake, these cells ...
Human macrophage polarization shapes B. pertussis intracellular persistence
(Society for Leukocyte Biology, 2022-07)
We previously demonstrated that Bordetella pertussis, the etiologic agent of whooping cough, is able to survive inside human macrophages. The aim of this study was to examine the influence of macrophage polarization in the ...
Secreted factors by Anaplastic Thyroid Cancer Cells Induce Tumor-Promoting M2-like Macrophage Polarization through a TIM3-Dependent Mechanism
(Multidisciplinary Digital Publishing Institute, 2021-10)
Anaplastic thyroid cancer (ATC) is a highly aggressive type of thyroid cancer (TC). Currently, no effective target treatments are available that can improve overall survival, with ATC representing a major clinical challenge ...
Platelets promote macrophage polarization toward pro-inflammatory phenotype and increase survival of septic mice
(Cell Press, 2019-07)
We investigated the contribution of human platelets to macrophage effector properties in the presence of lipopolysaccharide (LPS), as well as the beneficial effects and time frame for platelet transfusion in septic animals. ...
M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry
(Elsevier Inc., 2018-10)
Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) g priming of naive macrophages induces ...
Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages
(American Physiological Society, 2014-09)
Endoplasmic reticulum (ER) stress is a prominent mechanism of macrophage apoptosis in advanced atherosclerotic lesions. Recent studies from our laboratory showed that advanced atherosclerotic plaques in Apoe-/- mice with ...
Galphai1 and Galphai3 regulate macrophage polarization by forming a complex containing CD14 and Gab1
(National Academy of Sciences, 2015-04-14)
Heterotrimeric G proteins have been implicated in Toll-like receptor 4 (TLR4) signaling in macrophages and endothelial cells. However, whether guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Gαi1/3) ...
M1-like macrophage polarization prevails in young children with classic Hodgkin Lymphoma from Argentina
(Nature Publishing Group, 2019-09)
The microenvironment in classical Hodgkin lymphoma (cHL) comprises a mixture of different types of cells, which are responsible for lymphoma pathogenesis and progression. Even though microenvironment composition in adult ...