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VIP induces the decidualization program and conditions the immunoregulation of the implantation process
(Elsevier Ireland, 2018-01)
The decidualization process involves phenotype and functional changes on endometrial cells and the modulation of mediators with immunoregulatory properties as the vasoactive intestinal peptide (VIP). We investigate VIP ...
Immunoregulation of the decidualization program: focus on the endoplasmic reticulum stress
(BioScientifica, 2020-04)
Decidualization denotes the reprogramming of endometrial stromal cells that includes the secretion of different mediators like cytokines, chemokines, and the selective recruitment of immune cells. This physiological process ...
Untangling galectin-driven regulatory circuits in autoimmune inflammation
(Elsevier, 2018-04)
Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary ...
Regulatory functions of NK cells during infections and cancer
(Federation of American Societies for Experimental Biology, 2021-01)
After recognition, NK cells can kill susceptible target cells through perforin-dependent mechanisms or by inducing death receptor-mediated apoptosis, and they can also secrete cytokines that are pivotal for immunomodulation. ...
Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities
(Springer, 2021-10)
Galectins, a family of highly conserved β-galactoside-binding proteins, control tumor progression by modulating different hallmarks of cancer. Galectin-1 (Gal-1), a proto-type member of this family, plays essential roles ...
Pathomechanisms of autoimmune based testicular inflammation
(Frontiers Media, 2020-09)
Infection and inflammation of the male reproductive tract are relevant causes of infertility. Inflammatory damage occurs in the special immunosuppressive microenvironment of the testis, a hallmark termed testicular immune ...
Trophoblast VIP deficiency entails immune homeostasis loss and adverse pregnancy outcome in mice
(Federation of American Societies for Experimental Biology, 2018-09)
Immune homeostasis maintenance throughout pregnancy is critical for normal fetal development. Trophoblast cells differentiate into an invasive phenotype and contribute to the transformation of maternal arteries and the ...
CD4+ Foxp3+ Regulatory T cells in autoimmune orchitis: phenotypic and functional characterization.
(Wiley, 2015-02)
Problem: The phenotype and function of regulatory T (Treg) cells in rats with experimental autoimmune orchitis (EAO) was evaluated. Method of study: Distribution of Treg cells in draining lymph nodes from the testis (TLN) ...
Local regulation of immune genes in rainbow trout (Oncorhynchus mykiss) naturally infected with Flavobacterium psychrophilum
(Elsevier, 2018)
Flavobacterium psychrophilum is the etiological agent of bacterial cold water disease (BCWD), also referred to as rainbow trout fry syndrome (RTFS), a disease with great economic impact in salmonid aquaculture. Despite ...
CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis
(BioMed Central, 2014)
Background: Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no ...