info:eu-repo/semantics/article
Untangling galectin-driven regulatory circuits in autoimmune inflammation
Fecha
2018-04Registro en:
Toscano, Marta Alicia; Martínez Allo, Verónica Candela; Cutine, Anabela María; Rabinovich, Gabriel Adrián; Mariño, Karina Valeria; Untangling galectin-driven regulatory circuits in autoimmune inflammation; Elsevier; Trends In Molecular Medicine; 24; 4; 4-2018; 348-363
1471-4914
CONICET Digital
CONICET
Autor
Toscano, Marta Alicia
Martínez Allo, Verónica Candela
Cutine, Anabela María
Rabinovich, Gabriel Adrián
Mariño, Karina Valeria
Resumen
Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary for developing more selective therapies. Galectins, a family of glycan-binding proteins, play central roles in immune cell homeostasis. Whereas some members of this family trigger regulatory programs that promote resolution of inflammation, others contribute to perpetuate autoimmune processes. Here we discuss the roles of endogenous galectins and their specific glycosylated ligands in shaping autoimmune responses by fueling, extinguishing or re-wiring immune circuits. Understanding the relevance of galectin-glycan interactions in autoimmune inflammation could help uncover novel pathways of tolerance breakdown, define molecular signatures for patient stratification and therapy responses and open new avenues for immune intervention.