Buscar
Mostrando ítems 1-10 de 40
Novel Nanostructured Polymeric Carriers to Enable Drug Delivery for Cardiovascular Diseases
(Bentham, 2015)
Applications of polymeric nanotechnologies for enabling therapies for cardiovascular diseases have
shown recent success. Both intravenous and oral administration have been investigated and
achieved different degrees of ...
Nanoantioxidant–Based silica particles as flavonoid carrier for drug delivery applications
(MDPI, 2020)
Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent ...
Development and Characterization of Florfenicol-Loaded BSA Nanoparticles as Controlled Release Carrier
(Springer New York LLC, 2019)
Florfenicol (FLO) is a broad-spectrum fluorinated antibiotic used for the treatment of bacterial diseases such as bovine respiratory disease (BRD) in cattle. FLO is a poorly soluble drug in aqueous solution, and its ...
β-Cyclodextrin-based nanosponges functionalized with drugs and gold nanoparticles
(MDPI, 2021)
Drugs are widely used as therapeutic agents; however, they may present some limitations. To overcome some of the therapeutic disadvantages of drugs, the use of beta-cyclodextrin-based nanosponges (beta CDNS) constitutes a ...
Construction of 6-thioguanine and 6-mercaptopurine carriers based on βcyclodextrins and gold nanoparticles
(Elsevier, 2017)
As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG ...
Drug-loaded lipid-core micelles in mucoadhesive films as a novel dosage form for buccal administration of poorly water-soluble and biological drugs
(MDPI, 2020)
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive ...
STUDY OF THE DYNAMIC EFFECT OF CHOLESTEROL LOWERING DRUGS USING A MATHEMATICAL MODEL
(2007)
It is widely accepted that cholesterol plays an important role in the infiltration and entrapment
of low density lipoprotein (LDL) in the blood vessel walls (atherogenesis). The transport of
cholesterol and other lipids ...
Medicinal chemistry targeting mitochondria: From new vehicles and pharmacophore groups to old drugs with mitochondrial activity
(MDPI, 2020)
Interest in tumor cell mitochondria as a pharmacological target has been rekindled in recent years. This attention is due in part to new publications documenting heterogenous characteristics of solid tumors, including ...
Spray Freeze-Drying as an Alternative to the Ionic Gelation Method to Produce Chitosan and Alginate Nano-Particles Targeted to the Colon
(Wiley & Sons, 2015)
Chitosan and alginate nano-composite (NP) carriers intended for colonic delivery containing prednisolone and inulin were obtained by two processes. Spray freeze-drying using chitosan (SFDC) or alginate (SFDA) was proposed ...
Novel strategies for the buccal delivery of macromolecules
(Informa Healthcare, 2014)
For years now, the delivery of small molecules through the buccal mucosal route has been described in the literature, but it has only been over the past decade that investigations into macromolecule delivery via the buccal ...