Artículo de revista
Novel strategies for the buccal delivery of macromolecules
Fecha
2014Registro en:
Drug Development and Industrial Pharmacy, Volumen 40, Issue 5, 2018, Pages 579-590
15205762
03639045
10.3109/03639045.2014.892960
Autor
Morales, Javier O.
McConville, Jason T.
Institución
Resumen
For years now, the delivery of small molecules through the buccal mucosal route has been described in the literature, but it has only been over the past decade that investigations into macromolecule delivery via the buccal route have sharply increased. The administration of macromolecules such as proteins and peptides, antibodies, or nucleic acids by buccal administration would be greatly enhanced due to the avoidance of the gastrointestinal conditions, rapid uptake into systemic circulation, as well as the potential for controlled drug delivery. Since macromolecules are faced with a number of specific challenges related to permeation through the epithelium, several strategies have been employed historically to improve their buccal absorption and subsequent bioavailability. Several conventional strategies to improve macromolecule penetration include the use of chemical permeation enhancers, enzyme inhibitors and the use of mucoadhesive materials acting as carriers. More recent approach