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Contributions of DNA repair, cell cycle checkpoints and cell death to suppressing the DNA damage-induced tumorigenic behavior of Drosophila epithelial cells
(Nature Publishing Group, 2015-02)
When exposed to DNA-damaging agents, components of the DNA damage response (DDR) pathway trigger apoptosis, cell cycle arrest and DNA repair. Although failures in this pathway are associated with cancer development, the ...
Fabrication of a novel biosensor for biosensing of bisphenol A and detection of its damage to DNA
(Elsevier Science, 2019-04)
In this work, a novel electrochemical biosensor has been fabricated based on step-by-step modification of aglassy carbon electrode (GCE) with methylene blue (MB)-DNA/multiwalled carbon nanotubes (MWCNTs)-chitosan (CS)/palladium ...
E2F1 and E2F2 induction in response to DNA damage preserves genomic stability in neuronal cells
(Taylor & Francis, 2015-04)
E2F transcription factors regulate a wide range of biological processes, including the cellular response to DNA damage. In the present study, we examined whether E2F family members are transcriptionally induced following ...
Intra- and extracellular DNA damage by harmine and 9-methyl-harmine
(Elsevier Science Sa, 2014-02-13)
It is known that b-carbolines are able to produce photosensitized damage in cell-free DNA, but there is little information on their effects on cellular DNA. Therefore, we have analyzed the DNA damage produced by harmine ...
Rad51 prevents Mre11-dependent degradation and excessive primpol-mediated elongation of nascent DNA after UV irradiation
(National Academy Of Sciences, 2015-12)
After UV irradiation, DNA polymerases specialized in translesion DNA synthesis (TLS) aid DNA replication. However, it is unclear whether other mechanisms also facilitate the elongation of UV-damaged DNA. We wondered if ...
Fabrication of a novel impedimetric biosensor for label free detection of DNA damage induced by doxorubicin
(Elsevier Science, 2019-02)
In this work, a novel impedimetric biosensor has been fabricated for detection of DNA damage induced by doxorubicin (DX). Cytochrome P450 reductase (CPR) is required for electron transfer from nicotinamide adenine dinucleotide ...
ERIC-PCR technique applied to monitoring and quantification of DNA damage during water disinfection process
(Elsevier Science Sa, 2019-11)
In this work, we propose a novel application of ERIC-PCR technique to study DNA damage after ultraviolet radiation (UV) and peracetic acid (PAA) treatment for water disinfection purpose. The efficacy of both treatments on ...
Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA damage responses
(Fundação Oswaldo Cruz, 2020-07)
BACKGROUND NME23/NDPKs are well conserved proteins found in all living organisms. In addition to being nucleoside diphosphate kinases (NDPK), they are multifunctional enzymes involved in different processes such as DNA ...
DNA and chromosome damage induced by bleomycin in mammalian cells: An update
(Elsevier Science, 2018-01)
Bleomycin (BLM) is an antibiotic isolated from Streptomyces verticillus. It has radiomimetic actions on DNA thus it has been widely used in clinical chemotherapy for the treatment of different types of cancer, including ...
Reciprocal regulation between alternative splicing and the DNA damage response
(Sociedade Brasileira de Genética, 2020-03)
Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, ...