info:eu-repo/semantics/article
Reciprocal regulation between alternative splicing and the DNA damage response
Fecha
2020-03Registro en:
Cambindo Botto, Adrian Edgardo; Muñoz, Juan Cristóbal; Giono, Luciana Eugenia; Nieto Moreno, Nicolás; Cuenca, Carmen; et al.; Reciprocal regulation between alternative splicing and the DNA damage response; Sociedade Brasileira de Genética; Genetics and Molecular Biology; 43; 1; 3-2020; 1-6
1678-4685
CONICET Digital
CONICET
Autor
Cambindo Botto, Adrian Edgardo
Muñoz, Juan Cristóbal
Giono, Luciana Eugenia
Nieto Moreno, Nicolás
Cuenca, Carmen
Kornblihtt, Alberto Rodolfo
Muñoz, Manuel J.
Resumen
Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transcriptome. Since 95% of the human coding genome is subjected to alternative splicing regulation, it is expected that many cellular pathways are modulated by alternative splicing, as is the case for the DNA damage response. Moreover, recent evidence demonstrates that upon a genotoxic insult, classical DNA damage response kinases such as ATM, ATR and DNA-PK orchestrate the gene expression response therefore modulating alternative splicing which, in a reciprocal way, shapes the response to a damaging agent.