A comparison of mucosal surface area and villous histology in small intestines of the brazilian free-tailed bat (Tadarida brasiliensis) and the mouse (Mus musculus)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorZhang, Zhi-Qiang
dc.creatorBrun, Antonio
dc.creatorPrice, Edwin R.
dc.creatorCruz-Neto, Ariovaldo P.
dc.creatorKarasov, William H.
dc.creatorCaviedes-Vidal, Enrique
dc.date2015-10-21T13:13:25Z
dc.date2016-10-25T21:00:26Z
dc.date2015-10-21T13:13:25Z
dc.date2016-10-25T21:00:26Z
dc.date2015-01-01
dc.date.accessioned2017-04-06T09:01:08Z
dc.date.available2017-04-06T09:01:08Z
dc.identifierJournal Of Morphology. Hoboken: Wiley-blackwell, v. 276, n. 1, p. 102-108, 2015.
dc.identifier0362-2525
dc.identifierhttp://hdl.handle.net/11449/128776
dc.identifierhttp://acervodigital.unesp.br/handle/11449/128776
dc.identifierhttp://dx.doi.org/10.1002/jmor.20324
dc.identifierWOS:000347054600008
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/jmor.20324/abstract;jsessionid=DA725C1C2425B1AAEBC79CFD715A8343.f02t03
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/939332
dc.descriptionStudies on birds have led to the hypothesis that increased intestinal absorption between enterocytes (paracellular) evolved as a compensation for smaller intestinal size in fliers, which was perhaps selected to minimize the mass of digesta carried. This hypothesis predicts that bats will also exhibit relatively reduced intestinal size and high paracellular absorption, compared with nonflying mammals. Published studies on three bat species indicate relatively high paracellular absorption. One mechanism for increasing paracellular absorption per cm(2) small intestine (SI) is increased number of tight junctions (TJs) across which paracellular absorption occurs. To our knowledge, we provide the first comparative analysis of enterocyte size and number in flying and nonflying mammals. Intestines of insectivorous bats Tadarida brasiliensis were compared with Mus musculus using hematoxylin and eosin staining method. Bats had shorter and narrower SIs than mice, and after correction for body size difference by normalizing to mass(3/4), the bats had 40% less nominal surface area than the mouse, as predicted. Villous enhancement of surface area was 90% greater in the bat than in the mouse, mainly because of longer villi and a greater density of villi in bat intestines. Bat and mouse were similar in enterocyte diameter. Bats exceeded mice by 54.4% in villous area per cm length SI and by 95% in number of enterocytes per cm(2) of the nominal surface area of the SI. Therefore, an increased density of TJs per cm(2) SI may be a mechanistic explanation that helps to understand the high paracellular absorption observed in bats compared to nonflying mammals. J. Morphol. 276:102-108, 2015. (c) 2014 Wiley Periodicals, Inc.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationJournal Of Morphology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBats
dc.subjectRodents
dc.subjectSmall intestine
dc.subjectIntestinal surface area enlargement factor
dc.subjectEnterocytes
dc.subjectParacellular absorption
dc.titleA comparison of mucosal surface area and villous histology in small intestines of the brazilian free-tailed bat (Tadarida brasiliensis) and the mouse (Mus musculus)
dc.typeOtro


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