info:eu-repo/semantics/article
Osseointegration improvement by plasma electrolytic oxidation of modified titanium alloys surfaces
Registro en:
0957-4530
10.1007/s10856-015-5408-4.
1573-4838
Autor
Echeverry Rendón, Mónica
Galvis Tangarife, Oscar Alonso
Quintero Giraldo, David
Pavón Palacio, Juan José
López Lacomba, José Luis
Jiménez Piqué, Emilio
Anglada, Marc
Robledo Restrepo, Sara María
Castaño González, Juan Guillermo
Echeverría Echeverría, Félix
Institución
Resumen
ABSTRACT: Titanium (Ti) is a material frequently used in orthopedic applications, due to its good
mechanical properties and high corrosion resistance. However, formation of a non‐adherent
fibrous tissue between material and bone drastically could affect the osseointegration process
and, therefore, the mechanical stability of the implant. Modifications of topography and
configuration of the tissue/ material interface is one of the mechanisms to improve that
process by manipulating parameters such as morphology and roughness. There are different
techniques that can be used to modify the titanium surface; plasma electrolytic oxidation
(PEO) is one of those alternatives, which consists of obtaining porous anodic coatings by
controlling parameters such as voltage, current, anodizing solution and time of the reaction.
From all of the above factors, and based on previous studies that demonstrated that bone cells
sense substrates features to grow new tissue, in this work commercially pure Ti (c.p Ti) and
Ti6Al4V alloy samples were modified at their surface by PEO in different anodizing solutions
composed of H2SO4 and H3PO4 mixtures. Treated surfaces were characterized and used as
platforms to grow osteoblasts; subsequently, cell behavior parameters like adhesion,
proliferation and differentiation were also studied. Although the results showed no significant
differences in proliferation, differentiation and cell biological activity, overall results showed
an important influence of topography of the modified surfaces compared with polished
untreated surfaces. Finally, this study offers an alternative protocol to modify surfaces of Ti
and their alloys in a controlled and reproducible way in which biocompatibility of the material
is not compromised and osseointegration would be improved. COL0007927 COL0144399 COL0015099