info:eu-repo/semantics/article
Human Papillomavirus Genotype Detection in Recurrent Respiratory Papillomatosis (RRP) in Colombia
Registro en:
1043-3074
10.1002/hed.22953
1097-0347
Autor
Sánchez Vásquez, Gloria Inés
Jaramillo Velásquez, Roberto
Cuello Bueno, Gustavo Adolfo
Quintero Martínez, Katherine
Baena Zapata, Armando
O’Byrne Olano, Adriana
Reyes Solarte, Antonio José
Santamaría Herrera, Consuelo
Cuello Bueno, Harold Daniel
Arrunátegui Ramírez, Ana María
Cortez, Armando
Osorio Sandoval, German
Reina Reina, Julio Cesar
Quint, Wim GV
Muñoz Calero, Nubia
Institución
Resumen
ABSTRACT: Background: Knowledge on human papillomavirus (HPV) genotype distribution in recurrent respiratory papillomatosis (RRP) is essential to assess the impact of HPV vaccine. It is provided information for Colombia. Methods: In all, 189 RRP primary cases diagnosed between 1985 and 2009 were identified from 5 pathology laboratories of Cali and Medellin, Colombia. HPV DNA testing in 129 cases that fulfilled inclusion criteria (available paraffin blocks, amplifiable DNA, and confirmed histologic diagnosis of RRP) was performed by the SPF-10/LiPA25 assay (version 1). Results: Of all cases 36.1% were juvenile (<12 years old) and a majority of adults were males (p = .09); 95% of cases were HPV positive. HPV 6, 11, and 16 contributed to 69%, 27.1%, and 7.8% of all HPV positive cases. Twelve cases (9.3%) showed multiple infections; 8 of these were HPV 6 or 11 positive. Conclusions: HPV prophylactic vaccine including HPV 6 and 11 may have a major impact against RRP. COL0024159
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