Chronic acrolein exposure in wistar rats: the effects of guarana extracts

Exposición crónica a acroleína en ratas wistar: los efectos de los extractos de guaraná

dc.creatorda Silva Bittencourt, Leonardo
dc.creatorSchnorr, Carlos Eduardo
dc.creatorCopetti Santos, Daniela
dc.creatorRostirolla, Diana Carolina
dc.creatorMoresco, Karla
dc.creatorOzório, Pedro
dc.creatorRodrigues Mingori, Moara
dc.creatorHeinfarth, Luana
dc.creatorGelain, Daniel
dc.creatorMoreira, José Cláudio Fonseca
dc.date2020-11-04T14:47:23Z
dc.date2020-11-04T14:47:23Z
dc.date2019-12-04
dc.date.accessioned2023-10-03T19:15:13Z
dc.date.available2023-10-03T19:15:13Z
dc.identifier17564646
dc.identifierhttps://hdl.handle.net/11323/7200
dc.identifierhttps://doi.org/10.1016/j.jff.2019.103733
dc.identifierCorporación Universidad de la Costa
dc.identifierREDICUC - Repositorio CUC
dc.identifierhttps://repositorio.cuc.edu.co/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9169272
dc.descriptionPrevious studies have reported that acrolein, may exert harmful effects on the brain. However, information regarding the neuroprotective properties of guarana against acrolein is not available. Due to the lack of research, we initiated the current study to investigate the effects of guarana extracts on acrolein-induced toxicity in the liver and the central nervous system of Wistar Rats. Twelve groups of 60 days old Wistar rats treated with guarana extracts (150, 250, and 350 mg/kg/day) for 8 weeks, were challenged with acrolein (2.5 mg/kg/day). Several parameters associated with oxidative damage to the brain and hepatic function, as well as behavior were evaluated. All tested concentrations of guarana extracts exerted protective effects against acrolein induced damage. No hepatic and oxidative damages or behavioral changes were observed in guarana control groups. To the best of our knowledge, this is the first study of its kind and therefore a milestone in this field.
dc.descriptionEstudios anteriores han informado que la acroleína puede ejercer efectos nocivos en el cerebro. Sin embargo, no se dispone de información sobre las propiedades neuroprotectoras del guaraná contra la acroleína. Debido a la falta de investigación, iniciamos el estudio actual para investigar los efectos de los extractos de guaraná sobre la toxicidad inducida por acroleína en el hígado y el sistema nervioso central de las ratas Wistar. Doce grupos de ratas Wistar de 60 días de edad tratadas con extractos de guaraná (150, 250 y 350 mg / kg / día) durante 8 semanas, fueron desafiados con acroleína (2.5 mg / kg / día). Se evaluaron varios parámetros asociados con el daño oxidativo del cerebro y la función hepática, así como el comportamiento. Todas las concentraciones probadas de extractos de guaraná ejercieron efectos protectores contra el daño inducido por acroleína. No se observaron daños hepáticos y oxidativos o cambios de comportamiento en los grupos de control de guaraná. Hasta donde sabemos, este es el primer estudio de este tipo y, por lo tanto, un hito en este campo.
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dc.formatapplication/pdf
dc.languageeng
dc.publisherCorporación Universidad de la Costa
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dc.rightsCC0 1.0 Universal
dc.rightshttp://creativecommons.org/publicdomain/zero/1.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.sourceJournal of Functional Foods
dc.sourcehttps://www.sciencedirect.com/science/article/pii/S1756464619306577?via%3Dihub
dc.subject2-Propenal
dc.subjectOxidative stress
dc.subjectGuarana
dc.subjectPolyphenols
dc.subjectCognitive impairment
dc.subjectNeurogenerative diseases
dc.subjectEstrés oxidativo
dc.subjectGuaraná
dc.subjectPolifenoles
dc.subjectDeterioro cognitivo
dc.subjectEnfermedades neurogenerativas
dc.titleChronic acrolein exposure in wistar rats: the effects of guarana extracts
dc.titleExposición crónica a acroleína en ratas wistar: los efectos de los extractos de guaraná
dc.typeArtículo de revista
dc.typehttp://purl.org/coar/resource_type/c_6501
dc.typeText
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/submittedVersion
dc.typehttp://purl.org/redcol/resource_type/ART
dc.typeinfo:eu-repo/semantics/acceptedVersion
dc.typehttp://purl.org/coar/version/c_ab4af688f83e57aa


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