Molecularly designed layer-by-layer (LbL) films to detect catechol using information visualization methods

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAoki, Pedro H. B.
dc.creatorAlessio, Priscila
dc.creatorFurini, Leonardo N.
dc.creatorConstantino, Carlos J. L.
dc.creatorNeves, Tácito T. A. T.
dc.creatorPaulovich, Fernando V.
dc.creatorDe Oliveira, Maria Cristina F.
dc.creatorOliveira, Osvaldo N.
dc.date2014-05-27T11:29:46Z
dc.date2016-10-25T18:50:04Z
dc.date2014-05-27T11:29:46Z
dc.date2016-10-25T18:50:04Z
dc.date2013-06-18
dc.date.accessioned2017-04-06T02:27:49Z
dc.date.available2017-04-06T02:27:49Z
dc.identifierLangmuir, v. 29, n. 24, p. 7542-7550, 2013.
dc.identifier0743-7463
dc.identifier1520-5827
dc.identifierhttp://hdl.handle.net/11449/75678
dc.identifierhttp://acervodigital.unesp.br/handle/11449/75678
dc.identifier10.1021/la304544d
dc.identifierWOS:000320748200048
dc.identifier2-s2.0-84879129354
dc.identifierhttp://dx.doi.org/10.1021/la304544d
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/896416
dc.descriptionThe control of molecular architectures has been exploited in layer-by-layer (LbL) films deposited on Au interdigitated electrodes, thus forming an electronic tongue (e-tongue) system that reached an unprecedented high sensitivity (down to 10-12 M) in detecting catechol. Such high sensitivity was made possible upon using units containing the enzyme tyrosinase, which interacted specifically with catechol, and by processing impedance spectroscopy data with information visualization methods. These latter methods, including the parallel coordinates technique, were also useful for identifying the major contributors to the high distinguishing ability toward catechol. Among several film architectures tested, the most efficient had a tyrosinase layer deposited atop LbL films of alternating layers of dioctadecyldimethylammonium bromide (DODAB) and 1,2-dipalmitoyl-sn-3-glycero-fosfo-rac-(1-glycerol) (DPPG), viz., (DODAB/DPPG)5/DODAB/Tyr. The latter represents a more suitable medium for immobilizing tyrosinase when compared to conventional polyelectrolytes. Furthermore, the distinction was more effective at low frequencies where double-layer effects on the film/liquid sample dominate the electrical response. Because the optimization of film architectures based on information visualization is completely generic, the approach presented here may be extended to designing architectures for other types of applications in addition to sensing and biosensing. © 2013 American Chemical Society.
dc.languageeng
dc.relationLangmuir
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDioctadecyl dimethylammonium bromides
dc.subjectElectrical response
dc.subjectImpedance spectroscopy
dc.subjectInformation visualization
dc.subjectInter-digitated electrodes
dc.subjectLayer-by-layer films
dc.subjectMolecular architecture
dc.subjectParallel coordinates
dc.subjectData handling
dc.subjectDeposits
dc.subjectElectronic tongues
dc.subjectGold deposits
dc.subjectInformation analysis
dc.subjectInformation systems
dc.subjectPhenols
dc.subjectGold
dc.titleMolecularly designed layer-by-layer (LbL) films to detect catechol using information visualization methods
dc.typeOtro


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