Anemia at one year is an independent risk factor of graft survival

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAndrade, Luís Gustavo Modelli de
dc.creatorAbrão, Juliana Maria Gera
dc.creatorCarvalho, Maria Fernanda Cordeiro
dc.date2014-05-27T11:26:22Z
dc.date2016-10-25T18:36:34Z
dc.date2014-05-27T11:26:22Z
dc.date2016-10-25T18:36:34Z
dc.date2012-02-01
dc.date.accessioned2017-04-06T01:57:10Z
dc.date.available2017-04-06T01:57:10Z
dc.identifierInternational Urology and Nephrology, v. 44, n. 1, p. 263-268, 2012.
dc.identifier0301-1623
dc.identifier1573-2584
dc.identifierhttp://hdl.handle.net/11449/73173
dc.identifierhttp://acervodigital.unesp.br/handle/11449/73173
dc.identifier10.1007/s11255-010-9854-0
dc.identifier2-s2.0-84861174754
dc.identifierhttp://dx.doi.org/10.1007/s11255-010-9854-0
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/893994
dc.descriptionBackground Post-transplant anemia is multifactorial and highly prevalent. Some studies have associated anemia with mortality and graft failure. The purpose of this study was to assess whether the presence of anemia at 1 year is an independent risk factor of mortality and graft survival. Methods All patients transplanted at a single center who survived at least 1 year after transplantation and showed no graft loss (n = 214) were included. Demographic and clinical data were collected at baseline and at 1 year. Patients were divided into two groups (anemic and nonanemic) based on the presence of anemia (hemoglobin<130 g/l in men and 120 g/l in women). Results Baseline characteristics such as age, gender, type of donor, CKD etiology, rejection, andmismatches were similar in both groups. Creatinine clearance was similar in both anemic and nonanemic groups (69.32 ± 29.8 × 75.69 ± 30.5 ml/mim; P = 0.17). A Kaplan- Meier plot showed significantly poorer death-censored graft survival in the anemic group, P = 0.003. Multivariate analysis revealed that anemic patients had a hazard ratio for the graft loss of 3.85 (95% CI: 1.49-9.96; P = 0.005). Conclusions In this study, anemia at 1 year was independently associated with death-censored graft survival and anemic patients were 3.8-fold more likely to lose the graft. © 2010 Springer Science+Business Media, B.V.
dc.languageeng
dc.relationInternational Urology and Nephrology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnemia
dc.subjectGraft survival
dc.subjectKidney
dc.subjectMortality
dc.subjectTransplant
dc.subjectcreatinine
dc.subjecthemoglobin
dc.subjectadult
dc.subjectanemia
dc.subjectblood
dc.subjectbody mass
dc.subjectchronic kidney failure
dc.subjectfemale
dc.subjectgraft survival
dc.subjecthuman
dc.subjectimmunology
dc.subjectKaplan Meier method
dc.subjectkidney transplantation
dc.subjectmale
dc.subjectmetabolism
dc.subjectmultivariate analysis
dc.subjectproportional hazards model
dc.subjectretrospective study
dc.subjectcontrolled study
dc.subjectcreatinine clearance
dc.subjectmajor clinical study
dc.subjectmortality
dc.subjectAdult
dc.subjectBody Mass Index
dc.subjectCreatinine
dc.subjectFemale
dc.subjectGraft Survival
dc.subjectHemoglobins
dc.subjectHumans
dc.subjectKaplan-Meier Estimate
dc.subjectKidney Transplantation
dc.subjectMale
dc.subjectMultivariate Analysis
dc.subjectProportional Hazards Models
dc.subjectRenal Insufficiency, Chronic
dc.subjectRetrospective Studies
dc.subjectYoung Adult
dc.titleAnemia at one year is an independent risk factor of graft survival
dc.typeOtro


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