Article
Targeting caspases in intracellular protozoan infections
Registro en:
GUILLERMO, Landi V. C. et al. Targeting caspases in intracellular protozoan infections. Immunopharmacology and Immunotoxicology, v.31, n.2, p.159–173, 2009.
0892-3973
10.1080/08923970802332164
1532-2513
Autor
Guillermo, Landi V. C.
Pereira, Wânia F.
Meis, Juliana de
Gomes, Flavia L. Ribeiro
Silva, Elisabeth M.
Palhares, Karina Kroll
Takiya, Christina M.
Lopes, Marcela F
Resumen
Caspases are cysteine aspartases acting either as initiators (caspases 8, 9, and 10) or executioners (caspases 3, 6, and 7) to induce programmed cell death by apoptosis. Parasite infections by certain intracellular protozoans increase host cell life span by targeting caspase activation. Conversely, caspase activation, followed by apoptosis of lymphocytes and other cells, prevents effective immune responses to chronic parasite infection. Here we discuss how pharmacological inhibition of caspases might affect the immunity to protozoan infections, by either blocking or delaying apoptosis. 2030-01-01