Physiology and immunity of the invasive giant African snail, Achatina (Lissachatina) fulica, intermediate host of Angiostrongylus cantonensis

dc.creatorLima, Mariana G.
dc.creatorAugusto, Ronaldo de C.
dc.creatorPinheiro, Jairo
dc.creatorThiengo, Silvana C.
dc.date2020-04-26T20:34:48Z
dc.date2020-04-26T20:34:48Z
dc.date2020
dc.date.accessioned2023-09-26T20:39:09Z
dc.date.available2023-09-26T20:39:09Z
dc.identifierLIMA, Mariana G. et al. Physiology and immunity of the invasive giant African snail, Achatina (Lissachatina) fulica, intermediate host of Angiostrongylus cantonensis. Developmental and Comparative Immunology, v. 105, p. 1-10, 2020.
dc.identifier0145-305X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40972
dc.identifier10.1016/j.dci.2019.103579
dc.identifier1879-0089
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8861360
dc.descriptionAs one of the most successful invasive land snail species, Achatina (Lissachatina) fulica Bowdich, 1822 has achieved wide global distribution, particularly in (sub)tropical regions, with further dispersal likely due to climate change. This species of giant African snails (up to 17 cm shell length) is a pest that has extensive negative impact on agriculture and can serve as vector for several parasites, including Angiostrongylus cantonensis, a nematode parasite that causes (human) eosinophilic meningitis, an emergent disease. Investigation showed that A. cantonensis infection negatively impacts the metabolism of A. fulica by depleting polysaccharide stores of the intermediate host, compromising the energy balance of the snail. A review of the literature indicates that A. fulica possesses potent innate type immune defenses to counter infection, including phagocytic hemocytes capable of deploying reactive oxygen species and lectins for non-self recognition, a serine protease-dependent coagulation response (not observed in other taxa of gastropods), as well as antimicrobial proteins including achacin, an antimicrobial protein. A recent chromosome level genome assembly will facilitate progressively detailed characterization of these immune features of A. fulica. We strongly encourage further immunological studies of A. fulica, ranging from organismal level to molecular biology to gain better understanding of the A. fulica internal defense response to nematode pathogens like A. cantonensis and the contribution of immune function to the invasiveness of (snail) species. Characterization of immunity of A. fulica, representing the understudied Stylommatophora (panpulmonate landsnails) will also broaden the comparative immunology of Gastropoda.
dc.description2022-12-31
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectAchatina fulica
dc.subjectAngiostrongylus cantonensis
dc.subjectImunologia
dc.subjectFisiologia
dc.subjectNematodos
dc.subjectAchatina fulica
dc.subjectImmunology
dc.subjectPhysiology
dc.subjectNematodes
dc.subjectAngiostrongylus cantonensis
dc.titlePhysiology and immunity of the invasive giant African snail, Achatina (Lissachatina) fulica, intermediate host of Angiostrongylus cantonensis
dc.typeArticle


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