Preprint
Global disparities in SARS-CoV-2 genomic surveillance
Registro en:
BRITO, Anderson F. et al. Global disparities in SARS-CoV-2 genomic surveillance. p. 1 - 24, Dec. 2021.
Autor
Brito, Anderson F.
Semenova, Elizaveta
Dudas, Gytis
Hassler, Gabriel W.
Kalinich, Chaney C.
Kraemer, Moritz U.G.
Ho, Joses
Tegally, Houriiyah
Githinji, George
Agoti, Charles N.
Matkin, Lucy E.
Whittaker, Charles
Howden, Benjamin P.
Sintchenko, Vitali
Zuckerman, Neta S.
Mor, Orna
Blankenship, Heather M.
Oliveira, Tulio de
Lyn, Raymond T. P
Siqueira, Marilda Agudo Mendonça Teixeira de
Resende, Paola Cristina
Vasconcelos, Ana Tereza R.
Spilki, Fernando R.
Aguiar, Renato Santana
Alexiev, Ivailo
Ivanov, Ivan N.
Philipova, Ivva
Carrington, Christine V. F.
Sahadeo, Nikita S. D.
Gurry, Céline
Maurer-Stroh, Sebastian
Naidoo, Dhamari
von Eije, Karin J
Perkins, Mark D.
van Kerkhove, Maria
Hill, Sarah C.
Sabino, Ester C.
Pybus, Oliver G.
Dye, Christopher
Bhatt, Samir
Flaxman, Seth
Suchard5, Marc A.
Grubaugh‡, Nathan D.
Baele, Guy
Faria, Nuno
Resumen
Genomic sequencing provides critical information to track the evolution and spread of
SARS-CoV-2, optimize molecular tests, treatments and vaccines, and guide public health
responses. To investigate the spatiotemporal heterogeneity in the global SARS-CoV-2 genomic
surveillance, we estimated the impact of sequencing intensity and turnaround times (TAT) on
variant detection in 167 countries. Most countries submit 5 genomes >21 days after sample
collection, and 77% of low and middle income countries sequenced <0.5% of their cases. We
found that sequencing at least 0.5% of the cases, with a TAT <21 days, could be a benchmark for
SARS-CoV-2 genomic surveillance efforts. Socioeconomic inequalities substantially impact our
ability to quickly detect SARS-CoV-2 variants, and undermine the global pandemic preparedness.