Article
Low prevalence of human gammaherpesvirus 8 (HHV-8) infection among HIV-infected pregnant women in Rio de Janeiro, Brazil
Registro en:
LOPES, Amanda de O. et al. Low prevalence of human gammaherpesvirus 8 (HHV-8) infection among HIV-infected pregnant women in Rio de Janeiro, Brazil. The Journal of Maternal-Fetal & Neonatal Medicine, v. 34, n. 20, p. 3458-3461, Oct. 2019.
1476-7058
10.1080/14767058.2019.1685967
1476-4954
Autor
Lopes, Amanda de O.
Lima, Lyana R. P.
Tozetto-Mendoza, Tania R.
Martinelli, Katrini G.
Morgado, Mariza G.
Pilotto, José H.
Paula, Vanessa Salete S. de
Resumen
Pregnant women coinfected with the human immunodeficiency virus (HIV) and human gammaherpesvirus
8 (HHV-8) are at higher risk of Kaposi’s sarcoma development, increased viral load,
and vertical transmission of these viruses. A total of 131 pregnant women infected with HIV
were examined for antibodies against HHV-8 latency-associated nuclear antigen (LANA) and lytic
antigens using immunofluorescence assays. The presence of HHV-8 DNA was confirmed using
real-time polymerase chain reaction (qPCR) and nested PCR. Overall, 0.8% (1/131) of the patients
contained antibodies to HHV-8 LANA and lytic antigens, and no HHV-8 DNA was detected. This
study, including a small population of HIV-infected pregnant women in Brazil, indicates a low
prevalence of HHV-8 seropositivity and absence of active infection in this group. However, a
potential role of HHV-8 in the increased transmission and pathogenic activity of HIV in pregnant
women is suggested. Attention should be given to the emergence of HHV-8 infection in this
population group in order to avoid comorbidities and transmission of HIV. 2023