Article
Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children
Registro en:
ZHAO, Ziqi et al. Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children. Advanced Science, v. 7, n. 18, p. 1-10, 2020.
2198-3844
10.1002/advs.201901996
Autor
Zhao, Ziqi
Shang, Ziwei
Vasconcelos, Zilton Farias Meira de
Li, Chunfeng
Jiang, Yisheng
Zu, Shulong
Zhang, Jingyi
Wang, Fengchao
Yao, Li
Jung, Jae U.
Brasil, Patricia
Moreira, Maria Elisabeth
Qin, Cheng-Feng
Kerin, Tara
Nielsen-Saines, Karin
Cheng, Genhong
Zhang, Xiaohui
Xu, Zhiheng
Resumen
Zika virus (ZIKV) has evolved into a global health threat because of its causal link to congenital Zika syndrome. ZIKV infection of pregnant women may cause a spectrum of abnormalities in children. In the studies in Brazil, a large cohort of children with perinatal exposure to ZIKV is followed, and a spectrum of neurodevelopmental abnormalities is identified. In parallel, it is demonstrated that infection of the mouse neonatal brain by a contemporary ZIKV strain instead of an Asian ancestral strain can cause microcephaly and various abnormal neurological functions. These include defects in social interaction and depression, impaired learning and memory, in addition to severe motor defects, which are present in adult mice as well as in the prospective cohort of children. Importantly, although mouse brains infected later after birth do not have apparent abnormal brain structure, those mice still show significant impairments of visual cortical functions, circuit organization, and experience-dependent plasticity. Thus, the study suggests that special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood.