CHEMICAL SYMPATHECTOMY BLOCKS ANDROGEN BIOSYNTHESIS DURING PREPUBERTY

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRosaesilva, AAM
dc.creatorGuimaraes, M. A.
dc.creatorLamanocarvalho, T. L.
dc.creatorKempinas, W. G.
dc.date2014-05-20T15:27:48Z
dc.date2016-10-25T18:02:43Z
dc.date2014-05-20T15:27:48Z
dc.date2016-10-25T18:02:43Z
dc.date1995-10-01
dc.date.accessioned2017-04-06T00:04:00Z
dc.date.available2017-04-06T00:04:00Z
dc.identifierBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 28, n. 10, p. 1109-1112, 1995.
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/11449/37725
dc.identifierhttp://acervodigital.unesp.br/handle/11449/37725
dc.identifierWOS:A1995TD30800013
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/880986
dc.descriptionTwenty-one-day old male Wistar rats were injected subcutaneously with guanethidine (GUA) at doses of 5 and 10 mg kg(-1) day(-1) for 20 days. Animals were sacrificed by decapitation during the prepubertal (41 days of age) and early-pubertal (51 days of age) periods of sexual development. The testes were collected, frozen in liquid N-2 and stored at -70 degrees C until determination of testicular progesterone (P): androstenedione (A) and testosterone (T). Higher levels of P (2.18 +/- 0.24 ng/g. control = 1.24 +/- 0.16 ng/g) associated with decreased levels of androgens (A = 0.26 +/- 0.06 ng/g and T = 2.05 +/- 0.19 ng/g; control = 1.86 +/- 0.76 ng/g and 8.48 +/- 1.16 ng/g, respectively) were observed in 10 mg GUA-treated rats of prepubertal age, while only P levels (3.12 +/- 0.51 ng/g control = 1.73 +/- 0.27 ng/g) were increased in rats of early pubertal age. It is important to note that in 41-day old male rats both 5 and 10 mg were effective in decreasing testicular concentration of testosterone. These results suggest that the sympathetic innervation of the testis is involved in the modulation of androgen biosynthesis, acting through a selective step in the steroid biochemical pathway during the pubertal process and that under the conditions employed the blockage in androgen biosynthesis in the prepubertal stage of sexual maturation is dependent on the dose of GUA.
dc.languageeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relationBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSYMPATHECTOMY
dc.subjectGUANETHIDINE
dc.subjectPROGESTERONE
dc.subjectANDROGENS
dc.subjectPUBERTY
dc.titleCHEMICAL SYMPATHECTOMY BLOCKS ANDROGEN BIOSYNTHESIS DURING PREPUBERTY
dc.typeOtro


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