Resenha
Postprandial proximal gastric acid pocket and gastroesophageal reflux disease
Fecha
2012-09-01Registro en:
Diseases of the Esophagus. Hoboken: Wiley-Blackwell, v. 25, n. 7, p. 652-655, 2012.
1120-8694
10.1111/j.1442-2050.2011.01293.x
WOS:000308712300012
Autor
Herbella, F. A. M. [UNIFESP]
Vicentine, F. P. P. [UNIFESP]
Silva, L. C. [UNIFESP]
Patti, M. G.
Institución
Resumen
An unbuffered layer of acidity that escapes neutralization by food has been demonstrated in volunteers and gastroesophageal reflux disease patients. This postprandial proximal gastric acid pocket (PPGAP) is manometrically defined by the presence of acid reading (pH < 4) in a segment of the proximal stomach between nonacid segments distally (food) and proximally (lower esophageal sphincter or distal esophagus). the PPGAP may have important clinical implications; however, it is still poorly understood. Gastric anatomy and physiology seem to be important elements for PPGAP genesis. Gastric operations and acid suppression medications may decrease distal proximal intragastric acid reflux and help control gastroesophageal reflux.