Hematological and biochemical profiles and histopathological evaluation of experimental intoxication by sodium fluoroacetate in cats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCollicchio-Zuanaze, R. C.
dc.creatorSakate, M.
dc.creatorLangrafe, L.
dc.creatorTakahira, Regina Kiomi
dc.creatorBurini, C.
dc.date2014-05-20T13:39:38Z
dc.date2016-10-25T16:55:19Z
dc.date2014-05-20T13:39:38Z
dc.date2016-10-25T16:55:19Z
dc.date2010-11-01
dc.date.accessioned2017-04-05T20:37:40Z
dc.date.available2017-04-05T20:37:40Z
dc.identifierHuman & Experimental Toxicology. London: Sage Publications Ltd, v. 29, n. 11, p. 903-913, 2010.
dc.identifier0960-3271
dc.identifierhttp://hdl.handle.net/11449/13755
dc.identifierhttp://acervodigital.unesp.br/handle/11449/13755
dc.identifier10.1177/0960327110362908
dc.identifierWOS:000283054100002
dc.identifier0000-0003-3323-4199
dc.identifierhttp://dx.doi.org/10.1177/0960327110362908
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860991
dc.descriptionSodium fluoroacetate (SFAC) is a potent rodenticide, largely used for rodent and domestic pest control. The toxic effects of SFAC are caused by fluoroacetate, a toxic metabolite, whose toxic action blocks the Krebs cycle and also induces the accumulation of citrate in the body, which is a serum calcium chelator. The most common clinical signs of this intoxication are the cardiac and neurological effects. However, the hematological, biochemical and histopathological findings occurring in intoxication are still unknown in different species. In the present study, 16 domestic cats were experimentally intoxicated with oral doses of fluoroacetate (0.45 mg/kg). The hematological and biochemical profiles and histopathological findings were made to look for auxiliary diagnosis methods in SFAC intoxications. The hematological profile showed transitory leucopenia and thrombocytopenia; in the biochemical profiles were detected hyperglycemia, increase of creatinequinase enzyme (CK) and creatinequinase cardiac isoenzyme (CK-MB), hypokalemia and hypophosfatemia. In the macroscopic and histopathological findings were observed lesions characteristic of degenerative and ischemic processes in heart, kidneys, liver, brain and lungs. These changes may be auxiliary to the diagnosis of intoxication by SFAC in cats, when associated with clinical signs described for the species. Thus, the complete blood count with platelet count, serum glucose, enzymes CK and CK-MB isoenzyme, as well as the electrolytes potassium and phosphorus, can facilitate the laboratory diagnosis during intoxication by SFAC, associated with the pathological findings in the case of death of the intoxicated animal.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherSage Publications Ltd
dc.relationHuman & Experimental Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsodium fluoroacetate
dc.subjectcats
dc.subjecthematology
dc.subjectserum biochemistry
dc.subjecthistopathology
dc.subjectdiagnosis
dc.subjectintoxication
dc.titleHematological and biochemical profiles and histopathological evaluation of experimental intoxication by sodium fluoroacetate in cats
dc.typeOtro


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