Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid

dc.creatorÁlvarez Larrotta, Catalina
dc.creatorAgudelo García, Olga María
dc.creatorGavina, Kenneth
dc.creatorYanow, Stephanie Kim
dc.creatorMaestre Buitrago, Amanda Elena
dc.creatorCarmona Fonseca, Jaime
dc.creatorArango Flórez, Eliana María
dc.date2022-11-21T14:49:51Z
dc.date2022-11-21T14:49:51Z
dc.date2019
dc.date.accessioned2023-08-28T19:51:50Z
dc.date.available2023-08-28T19:51:50Z
dc.identifierÁlvarez-Larrotta C, Agudelo OM, Duque Y, Gavina K, Yanow SK, Maestre A, Carmona-Fonseca J, Arango E. Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid. Clin Exp Immunol. 2019 Jan;195(1):96-108. doi: 10.1111/cei.13213.
dc.identifier0009-9104
dc.identifierhttps://hdl.handle.net/10495/32164
dc.identifier10.1111/cei.13213
dc.identifier1365-2249
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8469862
dc.descriptionABSTRACT: Submicroscopic Plasmodium infections in pregnancy are common in endemic areas, and it is important to understand the impact of these low-level infections. Asymptomatic, chronic infections are advantageous for parasite persistence, particularly in areas where the optimal eco-epidemiological conditions for parasite transmission fluctuate. In chronic infections, the persistence of the antigenic stimulus changes the expression of immune mediators and promotes constant immune regulation, including increases in regulatory T cell populations. These alterations of the immune system could compromise the response to routine vaccination. This study aimed to evaluate the effect of submicroscopic plasmodial infection with P. falciparum and P. vivax during pregnancy on the immune response to the tetanus toxoid vaccine in Colombian women. Expression of different cytokines and mediators of immune regulation and levels of anti-tetanus toxoid (TT) immunoglobulin (Ig)G were quantified in pregnant women with and without submicroscopic plasmodial infection. The anti-TT IgG levels were significantly lower in the infected group compared with the uninfected group. The expression of interferon (IFN)-γ, tumour necrosis factor (TNF) and forkhead box protein 3 (FoxP3) was significantly higher in the infected group, while the expression of cytotoxic T lymphocyte antigen 4 (CTLA-4) and transforming growth factor (TGF)-β was lower in the group of infected. In conclusion, submicroscopic Plasmodium infection altered the development of the immune response to the TT vaccine in Colombian pregnant women. The impact of Plasmodium infections on the immune regulatory pathways warrants further exploration.
dc.descriptionCOL0047449
dc.format13
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherBritish Society for Immunology
dc.publisherSalud y Comunidad
dc.publisherOxford, Inglaterra
dc.relationClin Exp Immunol
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCitocinas
dc.subjectCytokines
dc.subjectAnticuerpos Antibacterianos
dc.subjectAntibodies, Bacterial
dc.subjectEnfermedad Crónica
dc.subjectChronic Disease
dc.subjectLinfocitos T Reguladores
dc.subjectT-Lymphocytes, Regulatory
dc.subjectMalaria
dc.subjectPlasmodium falciparum
dc.subjectPlasmodium vivax
dc.subjectVacunas
dc.subjectVaccines
dc.subjectComplicaciones Infecciosas del Embarazo
dc.subjectPregnancy Complications, Infectious
dc.titleSubmicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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