Estudio de un sistema bio-electroquímico de fermentación para la producción de 1,3-propanodiol a partir de glicerina cruda

dc.contributorMontoya Castaño, Dolly
dc.contributorBioprocesos y Bioprospeccion
dc.contributorOSCAR LEONARDO ARAGON CAICEDO [0000000193632258]
dc.contributorhttps://www.researchgate.net/profile/Oscar-Aragon
dc.creatorAragón Caycedo, Oscar Leonardo
dc.date.accessioned2023-07-19T14:02:51Z
dc.date.accessioned2023-08-25T13:45:42Z
dc.date.available2023-07-19T14:02:51Z
dc.date.available2023-08-25T13:45:42Z
dc.date.created2023-07-19T14:02:51Z
dc.date.issued8-07-23
dc.identifierhttps://repositorio.unal.edu.co/handle/unal/84216
dc.identifierUniversidad Nacional de Colombia
dc.identifierRepositorio Institucional Universidad Nacional de Colombia
dc.identifierhttps://repositorio.unal.edu.co
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8427010
dc.description.abstractLos azúcares y el glicerol pueden servir como sustratos de bajo costo en aplicaciones biotecnológicas para obtener varios intermediarios químicos con un alto valor agregado. La electrofermentación es una reciente tecnología con la que es posible mejorar y controlar la fermentación microbiana, especialmente con cepas del género Clostridium, aumentando la especificidad de las vías metabólicas. En este contexto, cepas bacterianas aisladas de suelos colombianos, y estrechamente relacionadas con Clostridium butyricum, se han identificado como eficientes productoras de solventes y ácidos, incluidos ácido acético, ácido butírico, etanol, butanol, acetona e hidrógeno a partir de glucosa o 1,3-propanodiol a partir de glicerol. En este trabajo se evalúa el efecto del suministro externo de electrones en la producción de metabolitos de interés comercial con una red metabólica de C. butyricum. Los resultados obtenidos de un modelo de simulación señalan que la interacción con el electrodo catódico mejora los rendimientos de productos reducidos. En concreto, utilizando glicerol como sustrato, la simulación indicó que el rendimiento medio del producto podría aumentar con 1,3-propanodiol (23%) e hidrógeno (45%). Por último, se estableció experimentalmente que la cepa nativa IBUN 158B es electroactiva y tiene la capacidad de incrementar los valores de rendimiento producto / sustrato de 1,3-PD (7 – 9%) cuando es sometida a la alimentación de pequeñas cantidades de electrones desde un cátodo en un proceso electrofermentación catódica y que el uso de transportadores de electrones como el Rojo Neutral incrementa los efectos de la electrofermentación alcanzando mayores valores de rendimiento cuando está presente en el medio de cultivo. En conclusión, la electrofermentación de Clostridium butyricum como técnica de cultivo bioelectroquímico tiene potencial como proceso de producción alternativo a la fermentación tradicional para controlar el estado redox durante la síntesis de bioquímicos y aumentar la producción de metabolitos de interés comercial. Pero se necesita más investigación básica y aplicada para dilucidar los mecanismos de transferencia de electrones y revelar los mecanismos reguladores subyacentes. (Texto tomado de la fuente)
dc.description.abstractSugars and glycerol can serve as low-cost substrates in biotechnological applications to obtain various chemical intermediates with high added value. Electrofermentation is a recent technology with which it is possible to improve and control microbial fermentation, especially with strains of the Clostridium genus, increasing the specificity of metabolic pathways. In this context, bacterial strains isolated from Colombian soils, and closely related to Clostridium butyricum. These strains have been efficient producers of solvents and acids, including acetic acid, butyric acid, ethanol, butanol, acetone, and hydrogen from glucose or 1,3-propanediol from glycerol. In this work, the production of commercial interest metabolites is assessed using an electron external supply with a metabolic network of C. butyricum. The simulation results show that the interaction with the cathode electrode improves the reduced product rates. Specifically, using glycerol as a substrate, the average yield of the product increases with 1,3-propanediol (23%) and hydrogen (45%). Finally, it was established experimentally that the native strain IBUN 158B is electroactive and has the capacity to increase the product/substrate yield values of 1,3-PD (7-9%) when it is submitted to the feeding of small amounts of electrons from a cathode in a cathodic electrofermentation process and that the use of electron carriers such as Neutral Red increases the effects of electrofermentation, reaching higher yield values when it is present in the culture medium. In conclusion, the electrofermentation of Clostridium butyricum as a bioelectrochemical culture technique has potential as an alternative production process to traditional fermentation to control the redox state during the synthesis of biochemicals and increase the production of metabolites of commercial interest. More basic and applied research is necessary to elucidate the mechanisms of electron transfer and reveal the underlying regulatory mechanisms.
dc.languagespa
dc.publisherUniversidad Nacional de Colombia
dc.publisherBogotá - Ciencias - Doctorado en Biotecnología
dc.publisherFacultad de Ciencias
dc.publisherBogotá, Colombia
dc.publisherUniversidad Nacional de Colombia - Sede Bogotá
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dc.rightsReconocimiento 4.0 Internacional
dc.rightshttp://creativecommons.org/licenses/by/4.0/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleEstudio de un sistema bio-electroquímico de fermentación para la producción de 1,3-propanodiol a partir de glicerina cruda
dc.typeTrabajo de grado - Doctorado


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