Proliferative diabetic retinopathy is associated with microalbuminuria in patients with type 2 diabetes

dc.creatorBoelter, Maria Cristina
dc.creatorGross, Jorge Luiz
dc.creatorCanani, Luis Henrique Santos
dc.creatorCosta, L.A. da
dc.creatorLisboa, Hugo Roberto Kurtz
dc.creatorTres, Glaucia Sarturi
dc.creatorLavinsky, Jacó
dc.creatorAzevedo, Mirela Jobim de
dc.date2010-04-24T04:15:43Z
dc.date2006
dc.identifier0100-879X
dc.identifierhttp://hdl.handle.net/10183/21206
dc.identifier000592783
dc.descriptionDiabetic retinopathy is one of the leading causes of blindness in working-age individuals. Diabetic patients with proteinuria or those on dialysis usually present severe forms of diabetic retinopathy, but the association of diabetic retinopathy with early stages of diabetic nephropathy has not been entirely established. A cross-sectional study was conducted on 1214 type 2 diabetic patients to determine whether microalbuminuria is associated with proliferative diabetic retinopathy in these patients. Patients were evaluated by direct and indirect ophthalmoscopy and grouped according to the presence or absence of proliferative diabetic retinopathy. The agreement of diabetic retinopathy classification performed by ophthalmoscopy and by stereoscopic color fundus photographs was 95.1% (kappa = 0.735; P < 0.001). Demographic information, smoking history, anthropometric and blood pressure measurements, glycemic and lipid profile, and urinary albumin were evaluated. On multiple regression analysis, diabetic nephropathy (OR = 5.18, 95% CI = 2.91-9.22, P < 0.001), insulin use (OR = 2.52, 95% CI = 1.47-4.31, P = 0.001) and diabetes duration (OR = 1.04, 95% CI = 1.01-1.07, P = 0.011) were positively associated with proliferative diabetic retinopathy, and body mass index (OR = 0.90, 95% CI = 0.86-0.96, P < 0.001) was negatively associated with it. When patients with macroalbuminuria and on dialysis were excluded, microalbuminuria (OR = 3.3, 95% CI = 1.56-6.98, P = 0.002) remained associated with proliferative diabetic retinopathy. Therefore, type 2 diabetic patients with proliferative diabetic retinopathy more often presented renal involvement, including urinary albumin excretion within the microalbuminuria range. Therefore, all patients with proliferative diabetic retinopathy should undergo an evaluation of renal function including urinary albumin measurements.
dc.formatapplication/pdf
dc.languageeng
dc.relationBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 39, no. 8 (Aug. 2006), p. 1033-1039.
dc.rightsOpen Access
dc.subjectRetinopatia diabética
dc.subjectNefropatias diabéticas
dc.subjectMicroalbuminúria
dc.subjectDiabetes mellitus tipo 2
dc.subjectDiabetic retinopathy
dc.subjectDiabetic nephropathy
dc.subjectMicroalbuminuria
dc.subjectType 2 diabetes mellitus
dc.titleProliferative diabetic retinopathy is associated with microalbuminuria in patients with type 2 diabetes
dc.typeArtigo de periódico
dc.typeNacional


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