Artículos de revistas
Microbiological assay for lomefloxacin in coated tablets
Fecha
2006-01-01Registro en:
Journal of AOAC International, v. 89, n. 4, p. 1077-1079, 2006.
1060-3271
10.1093/jaoac/89.4.1077
2-s2.0-33750694271
Autor
Universidade Estadual Paulista (UNESP)
Institución
Resumen
The validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.