Artículos de revistas
A core outcome set for pre-eclampsia research: an international consensus development study
Fecha
2020-11-01Registro en:
BJOG: An International Journal of Obstetrics and Gynaecology, v. 127, n. 12, p. 1516-1526, 2020.
1471-0528
1470-0328
10.1111/1471-0528.16319
2-s2.0-85087149699
Autor
University of Oxford
University College London
Academic Medical Centre
Imperial College London
St George Hospital and University of New South Wales
King's College London
Northwestern University
Cedars-Sinai Medical Center
St George's University of London
London North West University Healthcare NHS Trust
Monash University
University of Adelaide
Barts and the London School of Medicine and Dentistry
University of Sheffield
University of Liverpool
Centro Rosarino de Estudios Perinatales
Chelsea and Westminster Hospital NHS Foundation Trust
Babcock University
Ailem Academic Counselling
KU Leuven
Universidad Nacional de Colombia
Northwell Health
Université de Montréal
University of Montreal Hospital Centre
Ondokuz Mayis University
Prince Sultan Military Medical City
Chandigarh
University Hospital Limerick
Drexel University
University of Aberdeen
University of Groningen
University of Auckland
Haaglanden Medisch Centrum
Nottingham University Medical School
Utrecht University
King Edward Memorial Hospital for Women
Imperial College Healthcare NHS Trust
Jean-Verdier Hospital
Downland Practice
Universidade Estadual de Campinas (UNICAMP)
Université Lyon
University of North Carolina School of Medicine
South Ural State Medical University
Stellenbosch University
Irish Neonatal Health Alliance
University of Rzeszow
Royal Brisbane and Women's Hospital
Nottingham University Hospitals NHS Trust
University Hospitals of Leicester
North Bristol NHS Trust
University of Nottingham
Soroka University Medical Centre Ben Gurion University of the Negev
St George's University Hospitals NHS Foundation Trust
Hospitalsenhed Midt
University of Glasgow
Postgraduate Institute of Medical Education and Research
Amsterdam Universitair Medische Centra
All India Institute of Medical Sciences Patna
Luton and Dunstable University Hospital
Khyber Medical University Institution of Medical Sciences
Midwife Mid Essex Hospitals NHS Trust
University of Oulu
University of Michigan
Bastyr University
Irish Nurses and Midwives Organisation
University of Toronto
Barts Health NHS Trust
University Hospitals Plymouth NHS Trust
Burnet Institute
Aga Khan University
Medical University of Graz
Homerton University Hospital NHS Foundation Trust
Mount Royal University
Université de Paris
Royal Surrey County Hospital
University Hospital Southampton NHS Foundation Trust
University of Washington School of Nursing
Evelina London Children's Hospital Neonatal Unit
University of Sydney
University of Leicester
Academic Hospital of Udine
NHS Borders
Weill Cornell Medical College
University of Dundee
University of Edinburgh
South Australian Health and Medical Research Institute
Monash University and Monash Health
United Lincolnshire Hospitals NHS Trust
University of Kwa Zulu-Natal
Beatrix Hospital
Keele University
Nagpur
Institut Catala de la Salut. IdiapJgol
National Centre for Child Health and Development
Basavatarakam Indo-American Cancer Hospital and Research Institute
Axon Anaesthesia Associates
Pennine Acute Hospitals NHS Trust
University of London
Norfolk and Norwich University Hospital
Jichi Medical University School of Medicine
Universidade Estadual Paulista (UNESP)
National Institute of Public Health
University of Kyrenia
King Edward Memorial Hospital
Amsterdam University Centres
University of British Columbia
Chulalongkorn University
University of Brescia
University of Montreal
Women's Clinic of Tartu University Hospital
Universidade Federal de São Paulo (UNIFESP)
Université de Sherbrooke
University Hospital of Wales
University of Iowa
Westmead Hospital
Princess Royal Maternity
Leipzig University
Centre Hospitalier Public du Cotentin
Lewisham and Greenwich NHS Trust
Juntendo University Faculty of Medicine
Western Sydney University
National Institute of Health Research
University of Washington
Baylor College of Medicine
Capelle aan den Ijssel
Sanatorio Anchorena
Oxford University Hospitals NHS Foundation Trust
University of Leeds
Lahore
UPMC Magee Womens Hospital
Penn Medicine Princeton Health
Institución
Resumen
Objective: To develop a core outcome set for pre-eclampsia. Design: Consensus development study. Setting: International. Population: Two hundred and eight-one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated. Methods: Modified Delphi method and Modified Nominal Group Technique. Results: A long-list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre-eclampsia trials with those derived from thematic analysis of 30 in-depth interviews of women with lived experience of pre-eclampsia. Forty-seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small-for-gestational-age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support. Conclusions: The core outcome set for pre-eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies. Tweetable abstract: 281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.].