Artículos de revistas
Evaluation of antileishmanial activity of harzialactone a isolated from the marine-derived fungus Paecilomyces sp
Fecha
2019-01-01Registro en:
Natural Product Research.
1478-6427
1478-6419
10.1080/14786419.2019.1619725
2-s2.0-85066809394
Autor
Universidade Estadual Paulista (Unesp)
Universidade de Franca
Universidade Federal de Mato Grosso
Universidade Federal do ABC (UFABC)
Institución
Resumen
Fractionation of extracts from the culture broth of the marine-derived fungus, Paecilomyces sp. 7A22, resulted in the isolation of the harzialactone A (HA), a known compound previously isolated from fungi of marine environments. The chemical structure of HA was determined by spectroscopic analyses. Upon evaluation of HA on antileishmanial assays against Leishmania amazonensis, HA exhibited significant activity against promastigotes forms with IC50 of 5.25 µg mL−1 and moderate activity against intracellular amastigotes with IC50 of 18.18 µg mL−1. This is the first report on the antileishmanial activity of HA, and the effects of HA presented in this work suggest that this class of compounds are suitable for future biological in vitro and in vivo studies for the search of natural products with activity against Leishmania spp. Furthermore, the present results corroborate marine-derived fungi as a promising source of natural products with antiparasitic activity.