info:eu-repo/semantics/article
Cantharidin-Based Small Molecules as Potential Therapeutic Agents
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Contiene 108 referencias bibliográficas. Véase documento adjunto
10.1111/cbdd.12180
Autor
Puerto Galvis, Carlos Eduardo
Vargas Méndez, Leonor Yamile
Kouznetsov, Vladimir V.
Resumen
Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles’ metabolites for the period 2006–2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models. Departamento Administrativo de Ciencia, Tecnología e Innovación [CO] Colciencias 5507-543-31904 Programa: Bioprospección y desarrollo de ingredientes naturales para las industrias cosmética, farmacéutica y de productos de aseo con base en la biodiversidad colombiana no