info:eu-repo/semantics/article
The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina
Fecha
2018-01Registro en:
Rolandelli, Agustin; Pellegrini, Joaquín Miguel; Amiano, Nicolás Oscar; Santilli, Maria Cecilia; Morelli, María Paula; et al.; The IFNG rs1861494 single nucleotide polymorphism is associated with protection against tuberculosis disease in Argentina; MDPI; Genes; 9; 1; 1-2018; 1-12
2073-4425
CONICET Digital
CONICET
Autor
Rolandelli, Agustin
Pellegrini, Joaquín Miguel
Amiano, Nicolás Oscar
Santilli, Maria Cecilia
Morelli, María Paula
Castello, Florencia Andrea
Tateosian, Nancy Liliana
Levi, Alberto
Casco, Nicolás
Palmero, Domingo
García, Verónica Edith
Resumen
Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The IFNG rs1861494 polymorphism (G→A) was reported to alter the binding of transcription factors to this region, influencing IFNG production. Using a case-control study, we found an association between the AA and AG genotypes and tuberculosis resistance (AA vs. GG: odds ratio (OR) = 0.235, p-value = 0.012; AG vs. GG: OR = 0.303, p-value = 0.044; AA vs. AG: OR = 0.776, p-value = 0.427; AA + AG vs. GG: OR = 0.270, p-value = 0.022). Moreover, Mtb-antigen stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors and AA carriers secreted the highest amounts of IFNG in culture supernatants (p-value = 0.034) and presented the greatest percentage of CD4+IFNG+ lymphocytes (p-value = 0.035), in comparison with GG carriers. No association between the polymorphism and clinical parameters of tuberculosis severity was detected. However, our findings indicate that the rs1861494 single nucleotide polymorphism (SNP) could be considered as a biomarker of tuberculosis resistance in the Argentinean population.